国际放射医学核医学杂志
國際放射醫學覈醫學雜誌
국제방사의학핵의학잡지
INTERNATIONAL JOURNAL OF RADIATION MEDICINE AND NUCLEAR MEDICINE
2010年
6期
359-362
,共4页
糖尿病,2型%糖耐量受损%双峰型胰岛素释放曲线
糖尿病,2型%糖耐量受損%雙峰型胰島素釋放麯線
당뇨병,2형%당내량수손%쌍봉형이도소석방곡선
Diabetes mellitus,type 2%Impaired glucose toleration%Irregularity insulin release curve
目的 初步探讨双峰型胰岛素释放曲线(IRC)出现的原因.方法 以63例双峰型IRC2型糖尿病患者为双峰组、18名正常志愿者为对照组,进行口服葡萄糖耐量试验、胰岛素释放试验和C-肽释放试验,并计算稳态模型指标.结果 两组受试者的空腹血糖、空腹胰岛素、1 h胰岛素、空腹C-肽、1 h C-肽、Homa-1R差异无统计学意义;0.5 h血糖、1 h血糖、2 h血糖、3 h血糖、0.5 h胰岛素、2 h胰岛素、3 h胰岛素、0.5 hC-肽、2 h C-肽、3 hC-肽、血糖曲线下面积、胰岛素曲线下面积、C-肽曲线下面积、胰岛素分泌指数、△I30/△G30:双峰组＞对照组,△C-P30/△G30:双峰组＜对照组.结论 双峰组患者胰岛第一分泌相过度代偿,0.5 h胰岛素形成假性峰值而导致血糖增高,胰岛第二分泌相形成正常峰值,此组患者应为糖耐量受损.
目的 初步探討雙峰型胰島素釋放麯線(IRC)齣現的原因.方法 以63例雙峰型IRC2型糖尿病患者為雙峰組、18名正常誌願者為對照組,進行口服葡萄糖耐量試驗、胰島素釋放試驗和C-肽釋放試驗,併計算穩態模型指標.結果 兩組受試者的空腹血糖、空腹胰島素、1 h胰島素、空腹C-肽、1 h C-肽、Homa-1R差異無統計學意義;0.5 h血糖、1 h血糖、2 h血糖、3 h血糖、0.5 h胰島素、2 h胰島素、3 h胰島素、0.5 hC-肽、2 h C-肽、3 hC-肽、血糖麯線下麵積、胰島素麯線下麵積、C-肽麯線下麵積、胰島素分泌指數、△I30/△G30:雙峰組＞對照組,△C-P30/△G30:雙峰組＜對照組.結論 雙峰組患者胰島第一分泌相過度代償,0.5 h胰島素形成假性峰值而導緻血糖增高,胰島第二分泌相形成正常峰值,此組患者應為糖耐量受損.
목적 초보탐토쌍봉형이도소석방곡선(IRC)출현적원인.방법 이63례쌍봉형IRC2형당뇨병환자위쌍봉조、18명정상지원자위대조조,진행구복포도당내량시험、이도소석방시험화C-태석방시험,병계산은태모형지표.결과 량조수시자적공복혈당、공복이도소、1 h이도소、공복C-태、1 h C-태、Homa-1R차이무통계학의의;0.5 h혈당、1 h혈당、2 h혈당、3 h혈당、0.5 h이도소、2 h이도소、3 h이도소、0.5 hC-태、2 h C-태、3 hC-태、혈당곡선하면적、이도소곡선하면적、C-태곡선하면적、이도소분비지수、△I30/△G30:쌍봉조＞대조조,△C-P30/△G30:쌍봉조＜대조조.결론 쌍봉조환자이도제일분비상과도대상,0.5 h이도소형성가성봉치이도치혈당증고,이도제이분비상형성정상봉치,차조환자응위당내량수손.
Objective To investigate the reason for the appearance of bimodal insulin release curve (IRC). Methods Sixty-three cases of bimodal pattern of IRC (double hump group) were selected as experimental group; 18 normal volunteers as control group. Oral glucose tolerance test, insulin release test and C-peptide release test were performed, and the index of steady-state model was calculated. Results There were no significant difference among the two groups in fasting insulin, 1 hC-peptide, fasting plasma glucose, Homa-insulin resistance. 0.5 hIns: double hump group ＞ control group. Fasting C-peptide: control 1 group ＞double hump group ＞ normal Group. 0.5 h C-peptide: double hump group and control group ＞normal group. Fasting plasma glucose: normal group ＞ double hump group and control group. 0.5 h plasma gulcose: normal group ＞ double hump group ＞ control group. glucose area under curve: normal group ＞double hump group ＞ control group; △I30△ G30: double hump group ＞ control group ＞normal group. insulin area under curve and C-peptide area under curve: double hump group ＞ control group and normal group.There were significant difference among the results. Conclusions The pancreatic island has an overcompensation in the first secretion phase in double hump group, and the insulin displayed the pseudopeak value at 0.5 h which lead to the increase of blood glucose. The pancreatic island has a normal peak value in the second secretion phase, the patients in this group exsits impaired glucose tolerance.
