CAJ | 학술논문

目的探讨血小板相关抗体对血小板输注效果的影响.方法采用酶联免疫吸附试验(ELISA)检测120例长期反复输血并且需要输注血小板患者的血小板相关抗体,检测输血前后血小板计数,采用血小板计数增值考察血小板输注效果.采用简易致敏红细胞血小板血清学技术( SEPSA)对血小板相关抗体阳性患者进行血小板交叉配型后进行血小板输注.结果反复输血的患者中血小板相关抗体阳性率为65.0％,血小板输注的有效率为61.7％.血小板相关抗体阳性患者和阴性患者输注血小板时输注无效率分别为84.6％和19.0％,差异有统计学意义(x2=46.914,P＜0.01).对血小板相关抗体阳性患者采用SEPSA进行血小板配型后输注血小板有效率为85.9％.结论血小板相关抗体阳性与血小板输注无效相关,血小板配型可有效提高临床输注效果.
목적 탐토혈소판상관항체대혈소판수주효과적영향.방법 채용매련면역흡부시험(ELISA)검측120례장기반복수혈병차수요수주혈소판환자적혈소판상관항체,검측수혈전후혈소판계수,채용혈소판계수증치고찰혈소판수주효과.채용간역치민홍세포혈소판혈청학기술( SEPSA)대혈소판상관항체양성환자진행혈소판교차배형후진행혈소판수주.결과 반복수혈적환자중혈소판상관항체양성솔위65.0％,혈소판수주적유효솔위61.7％.혈소판상관항체양성환자화음성환자수주혈소판시수주무효솔분별위84.6％화19.0％,차이유통계학의의(x2=46.914,P＜0.01).대혈소판상관항체양성환자채용SEPSA진행혈소판배형후수주혈소판유효솔위85.9％.결론 혈소판상관항체양성여혈소판수주무효상관,혈소판배형가유효제고림상수주효과.
Objective To investigate effect of platelet-associated antibody to the platelet transfusion.Methods Platelet-associated antibody in 120 patients who needed repeated platelet transfusion for long-time was determined by enzyme-linked immunosorbent assay (ELISA),and platelet count was assayed before and after blood transfusion,and the effect of platelet transfusion was investigated by corrected platelet count.Crossmatch approcah was used to screen compatible platelet for patients with platelet relative antibody positive.Results The ratio of positive platelet-aasociated antibody in patients who needed repeated platelet transfusion was 65.0％,and the ratio of platelet transfusion resistance was 61.7％.The ratios of platelet transfusion resistance were 84.6％ and 19.0％ respectively in patients with positive platelet-associated antibody and in patients with negative platelet-associated antibody,which were different in statistic in both groups( x2 =,46.914,P ＜0.0l ).The effective ratio of platelet transfusion in patients with positive platelet-associated antibody after crossmatch approach was 85.9％.Conclusion Positive platelet-associated antibody was related to platelet transfusion resistance with high risk,and crossmatch approach could increase the effect of platelet transfusion.