CAJ | 학술논문

趋化因子是一种小分子量蛋白,参与T细胞分化、白细胞迁移、血管再生、肥大细胞脱颗粒等多种免疫功能.趋化因子受体为一种7次跨膜G蛋白耦联受体,趋化因子受体与趋化因子密切联系,共同构成生理及病理情况下复杂的网络系统,参与多种炎症性疾病以及自身免疫性疾病的发生与发展.趋化因子受体CXCR3及其配体,在系统性红斑狼疮(SLE)、类风湿性关节炎(RA)、干燥综合征(SS)3种自身免疫性疾病中发挥着重要作用.
추화인자시일충소분자량단백,삼여T세포분화、백세포천이、혈관재생、비대세포탈과립등다충면역공능.추화인자수체위일충7차과막G단백우련수체,추화인자수체여추화인자밀절련계,공동구성생리급병리정황하복잡적망락계통,삼여다충염증성질병이급자신면역성질병적발생여발전.추화인자수체CXCR3급기배체,재계통성홍반랑창(SLE)、류풍습성관절염(RA)、간조종합정(SS)3충자신면역성질병중발휘착중요작용.
Chemokines are low molecular weight proteins that orchestrate numerous immune functions such as T cell differentiation,leukocyte trafficking,angiogenesis,hematopeosis and mast cell degranulation.Their receptors are all seven-pass trans-membrane G-protein-coupled receptors.Chemokies and their receptors are intimately involved in a series of physiological and pathological conditions.Both of them play important parts in the pathogenesis of inflammation and autoimmune diseases.Here we briefly review the characteristics and functions of CXCR3,with special emphasis on its participation in three autoimmune diseases,namely systemic lupus erythematosus(SLE),rheumatoid arthritis(RA) and d Sj?gren syndrome(S S).