CAJ | 학술논문

目的回顾性分析已知大肠癌临床资料,为伺机性筛查策略及方案制定提供依据.方法收集2001年10月至2011年9月间华北地区五家医院收治的、具有完整记录并经组织学检查确诊的2450例大肠癌患者资料,分析年龄、性别、肿瘤发生部位和组织学类型与大肠癌发病的相关性.结果大肠癌患者中男性1377例,女性1073例;男∶女为1.28∶1;50岁以下占所有大肠癌病例的18.14％,50岁以上呈明显上升趋势;直乙结肠癌占73.00％,其他部位占27.00％(降结肠、横结肠、升结肠癌分别为6.12％,6.98％和13.9％);中分化腺癌占50.33％,高分化腺癌占40.35％,低分化腺癌占9.32％;分化程度与诊断年龄无明显相关性分化程度与诊断年龄、性别无明显相关性(P＞0.05).结论 50岁以下大肠癌所占比例上升,年轻化趋势,伺机性筛查不宜做年龄限制;推荐全结肠镜检查作为伺机性筛查精查手段;伺机性筛查不考虑性别差异.
목적 회고성분석이지대장암림상자료,위사궤성사사책략급방안제정제공의거.방법 수집2001년10월지2011년9월간화북지구오가의원수치적、구유완정기록병경조직학검사학진적2450례대장암환자자료,분석년령、성별、종류발생부위화조직학류형여대장암발병적상관성.결과 대장암환자중남성1377례,녀성1073례;남∶녀위1.28∶1;50세이하점소유대장암병례적18.14％,50세이상정명현상승추세;직을결장암점73.00％,기타부위점27.00％(강결장、횡결장、승결장암분별위6.12％,6.98％화13.9％);중분화선암점50.33％,고분화선암점40.35％,저분화선암점9.32％;분화정도여진단년령무명현상관성분화정도여진단년령、성별무명현상관성(P＞0.05).결론 50세이하대장암소점비례상승,년경화추세,사궤성사사불의주년령한제;추천전결장경검사작위사궤성사사정사수단;사궤성사사불고필성별차이.
Objective To retrospectively analyze medical data of patients with colorectal cancer (CRC) so as to provide evidence for clinical use of opportunistic screening.Methods A total of 2450 CRC patients (male 1377,female 1073) who were treated at five hospitals in North China during October 2001 and September 2011 and had complete medical records and pathological results were recruited.The correlations of incidence of CRC with age,gender,tumor location and histological types were analyzed.Results Of all the CRC patients,those less than 50 years old accounted for 18.14％ ; and the incidence of CRC was substantially increased in those over 50 years old.Seventy-three percent of tumor occurred at the rectum and sigmoid colon,6％ at descending colon,7％ at transverse colon and 14％ at ascending colon.Moderately,well or poorly differentiated adenocarcinoma accounted for 50.33％,40.35％and 9.32％,respectively.Histological differentiation was not correlated with age and gender ( P ＞ 0.05 ).Conclusions Age and gender should not be considered a determination of opportunistic screening for CRC.Colonoscopy is recommended as an alternative CRC screening procedure.