CAJ | 학술논문

目的比较渗出型老年性黄斑变性(nAMD)与息肉样脉络膜血管病变(PCV)患者年龄、性别及发病眼别的差异.方法以医院为基础的回顾性研究.经荧光素眼底血管造影(FFA)和吲哚青绿血管造影(ICGA)确诊的nAMD患者114例144只眼(nAMD组)和PCV患者145例186只眼(PCV组)纳入研究.统计其首诊年龄、性别、眼别等临床资料.两组患者年龄构成、性别及发病眼别的差异行两独立样本t检验和x 2检验.结果 nAMD组患者平均首诊年龄为(68.30±9.86)岁,PCV组患者平均首诊年龄为( 65.67±9.04)岁.两组患者平均首诊年龄比较,差异有统计学意义(t＝-2.168,P=0.031).首诊年龄小于70岁者,nAMD组中58例,占50.88％;PCV组中92例,占63.45％.PCV组首诊年龄＜70岁者比例高于nAMD组,差异有统计学意义(x2=4.138,P=0.042).nAMD组中男女比例为3.56∶1,PCV组中男女比例为2.02∶1,两组患者男女性别比比较,差异有统计学意义(x2=3.937,P=0.047).nAMD组中,双眼发病30例,占26.32％;PCV组中,双眼发病41例,占28.28％.两组患者双眼构成比比较,差异无统计学意义(x2 =0.123,P=0.726).nAMD组144只眼中,右眼69只眼,占47.92％;左眼75只眼,占52.08％.PCV组186只眼中,右眼92只眼,占49.46％,左眼94只眼,占50.54％.两组患者不同眼别构成比比较,差异无统计学意义(x2 =0.078,P＝0.637).结论 nAMD患者较PCV患者首诊年龄大;nAMD较PCV更容易发生在男性.两种疾病均有约1/4的患者双眼发病,眼别无差异.
목적 비교삼출형노년성황반변성(nAMD)여식육양맥락막혈관병변(PCV)환자년령、성별급발병안별적차이.방법 이의원위기출적회고성연구.경형광소안저혈관조영(FFA)화신타청록혈관조영(ICGA)학진적nAMD환자114례144지안(nAMD조)화PCV환자145례186지안(PCV조)납입연구.통계기수진년령、성별、안별등림상자료.량조환자년령구성、성별급발병안별적차이행량독립양본t검험화x 2검험.결과 nAMD조환자평균수진년령위(68.30±9.86)세,PCV조환자평균수진년령위( 65.67±9.04)세.량조환자평균수진년령비교,차이유통계학의의(t＝-2.168,P=0.031).수진년령소우70세자,nAMD조중58례,점50.88％;PCV조중92례,점63.45％.PCV조수진년령＜70세자비례고우nAMD조,차이유통계학의의(x2=4.138,P=0.042).nAMD조중남녀비례위3.56∶1,PCV조중남녀비례위2.02∶1,량조환자남녀성별비비교,차이유통계학의의(x2=3.937,P=0.047).nAMD조중,쌍안발병30례,점26.32％;PCV조중,쌍안발병41례,점28.28％.량조환자쌍안구성비비교,차이무통계학의의(x2 =0.123,P=0.726).nAMD조144지안중,우안69지안,점47.92％;좌안75지안,점52.08％.PCV조186지안중,우안92지안,점49.46％,좌안94지안,점50.54％.량조환자불동안별구성비비교,차이무통계학의의(x2 =0.078,P＝0.637).결론 nAMD환자교PCV환자수진년령대;nAMD교PCV경용역발생재남성.량충질병균유약1/4적환자쌍안발병,안별무차이.
Objective To compare neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) in age at diagnosis,gender and disease laterality.Methods One hundred fourteen nAMD patients (114 eyes) and 145 PCV patients (186 eyes) diagnosed by fundus fluorescein angiography (FFA) and indocyanine green angiography were enrolled in this retrospective study.The age at diagnosis,gender and disease laterality of all the patients were collected.Independent sample t-test,x2 test and Fisher's exact test were used to compare the age at diagnosis,gender and disease laterality between nAMD and PCV patients.Results The mean age at diagnosis of nAMD group and PCV group were (68.30±9.86),(65.67±9.04) years respectively,the difference was statistically significant (t=-2.168,P=0.031).The patients under 70 years old accounts for 50.88％ in nAMD group,which is lower than that in PCV group (63.45％),the difference was statistically significant (x2 =4.138,P=0.042).The male/female ratio of nAMD group and PCV group were 3.56:1 and 2.02∶1 respectively,the difference was statistically significant (x2=3.937,P=0.047).Thirty patients (26.32％) and 41 patients (49.46％) were affected unilaterally in nAMD and PCV group,respectively.The difference of bilateral incidence between two groups was not statistically significant (x2=0.123,P=0.726).There were 69 right eyes (47.92％)and 75 left eyes (52.08％) in nAMD group,92 right eyes (49.46％) and 94 left eyes (50.54％) in PCV group.The difference of disease laterality between two groups was not statistically significant (x2 =0.078,P=0.637).Conclusions PCV patients present at younger age than nAMD.nAMD is more prone to affected males than PCV.Nearly a quarter patients are bilateral in nAMD or PCV,there is no difference in bilateral incidence between these two diseases.