中华实验和临床病毒学杂志
中華實驗和臨床病毒學雜誌
중화실험화림상병독학잡지
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY
2009年
2期
103-105
,共3页
杨朝辉%祝双利%朱晖%安洪秋%毛乃颖%姬奕昕%郭学斌%尹少甫%张宗久%许文波
楊朝輝%祝雙利%硃暉%安洪鞦%毛迺穎%姬奕昕%郭學斌%尹少甫%張宗久%許文波
양조휘%축쌍리%주휘%안홍추%모내영%희혁흔%곽학빈%윤소보%장종구%허문파
肠道病毒B型,人%手足口病%血清流行病学研究
腸道病毒B型,人%手足口病%血清流行病學研究
장도병독B형,인%수족구병%혈청류행병학연구
Enterovirus B,human%Hand,foot and mouth disease%Serocpidemiologic studies
目的 了解2005年中国广东、黑龙江、新疆和云南四省、区1～5岁年龄儿童中的柯萨奇病毒A组16型(CVA16)抗体水平,为防控CVA16引起的手足口病的流行提供科学依据.方法 随机挑取上述四省、区2005年1～5岁年龄儿童血清503份进行CVA16的微量中和实验.结果 CVA16抗体阳性率在广东、黑龙江、新疆和云南分别为41.90%、9.40%、40.00%和34.40%.平均抗体滴度(GMT)均较低(平均为1:6.1),广东、黑龙江和云南各省内各年龄组间GMT差异无统计学意义(F值分别为0.97、0.40、1.06,P均>0.05),而四省、区间比较,黑龙江与其他三个省、区GMT差异有统计学意义(F=10.61,P<0.00).结论 2005年或以前CVA16已经在四省、区存在局部流行,但是不同省、区间的CVA16流行传播范围和程度不相同;1～5岁年龄段儿童是CVA16的易感人群.
目的 瞭解2005年中國廣東、黑龍江、新疆和雲南四省、區1～5歲年齡兒童中的柯薩奇病毒A組16型(CVA16)抗體水平,為防控CVA16引起的手足口病的流行提供科學依據.方法 隨機挑取上述四省、區2005年1～5歲年齡兒童血清503份進行CVA16的微量中和實驗.結果 CVA16抗體暘性率在廣東、黑龍江、新疆和雲南分彆為41.90%、9.40%、40.00%和34.40%.平均抗體滴度(GMT)均較低(平均為1:6.1),廣東、黑龍江和雲南各省內各年齡組間GMT差異無統計學意義(F值分彆為0.97、0.40、1.06,P均>0.05),而四省、區間比較,黑龍江與其他三箇省、區GMT差異有統計學意義(F=10.61,P<0.00).結論 2005年或以前CVA16已經在四省、區存在跼部流行,但是不同省、區間的CVA16流行傳播範圍和程度不相同;1～5歲年齡段兒童是CVA16的易感人群.
목적 료해2005년중국엄동、흑룡강、신강화운남사성、구1～5세년령인동중적가살기병독A조16형(CVA16)항체수평,위방공CVA16인기적수족구병적류행제공과학의거.방법 수궤도취상술사성、구2005년1～5세년령인동혈청503빈진행CVA16적미량중화실험.결과 CVA16항체양성솔재엄동、흑룡강、신강화운남분별위41.90%、9.40%、40.00%화34.40%.평균항체적도(GMT)균교저(평균위1:6.1),엄동、흑룡강화운남각성내각년령조간GMT차이무통계학의의(F치분별위0.97、0.40、1.06,P균>0.05),이사성、구간비교,흑룡강여기타삼개성、구GMT차이유통계학의의(F=10.61,P<0.00).결론 2005년혹이전CVA16이경재사성、구존재국부류행,단시불동성、구간적CVA16류행전파범위화정도불상동;1～5세년령단인동시CVA16적역감인군.
Objective To study the situation of 1-5 years old children's antibody against Coxsackieviras A group 16 strain( CVA16 )in Guangdong, Heilongjiang, Yunnan Province and Xinjiang Uygur Autonomous Regions, China,2005, it can offer scientific evidences for preventing and controlling CVA16 causative hand-food and mouth disease. Methods Using microneutrilisation test, to study 503 serum samples randomly selected from sera collected in 2005.Resulte. Positive rate of anti-CVA16 antibody were 41.90%, 9.40%, 40.00% and 34.40% in Gnangdong, Heilongjiang, Yunnan and Xinjiang, respectively. Antibody titer was relative low( average, 1:6.1 ) and there was no statistical difference of geometry mean of antibody titer (GMT) among Guangdong, Heilongjiang, Yunnan ( F = 0.97,0.40, 1.06, respectively; P > 0.05 ), while there had statistical difference of GMT between Heilongjiang and other three regions ( F = 10.61, P < 0.00). Conclusions There had probably existed local epidemic in some regions of Gnangdong, Heilongjiang, Yunnan Province and Xinjiang Uygur Autonomous Regions, China, 2005 or even before, but the area and degree of transmission and epidemic had difference. Children aged from 1-5 years old were relatively susceptible population of CVA16 infection.
