CAJ | 학술논문

目的研究腋下淋巴结阴性乳腺癌患者临床病理特征及其与人表皮生长因子受体-2(Her-2)表达的相关性及预后分析.方法收集自2003年至2009年期间郑州大学第三附属医院收治的278例原发性乳腺癌患者的临床资料,经病理检查证实腋下淋巴结为阴性.回顾性分析患者的临床病理特征、复发转移及生存情况,并进一步分析乳腺癌的预后影响因素.结果 278例原发性腋下淋巴结阴性乳腺癌患者中,肿块大小、雌激素受体(ER)及孕激素受体(PR)表达状态与Her-2蛋白表达水平明显相关(P＜0.05).另外,绝经状态、肿块大小、ER及PR表达状态与患者的5年无病率和5年生存率明显相关(P＜0.05).结论 ER及PR可作为预测腋下淋巴结为阴性的乳腺癌患者远期生存的重要指标,为乳腺癌治疗方案提供参考依据.
목적 연구액하림파결음성유선암환자림상병리특정급기여인표피생장인자수체-2(Her-2)표체적상관성급예후분석.방법 수집자2003년지2009년기간정주대학제삼부속의원수치적278례원발성유선암환자적림상자료,경병리검사증실액하림파결위음성.회고성분석환자적림상병리특정、복발전이급생존정황,병진일보분석유선암적예후영향인소.결과 278례원발성액하림파결음성유선암환자중,종괴대소、자격소수체(ER)급잉격소수체(PR)표체상태여Her-2단백표체수평명현상관(P＜0.05).령외,절경상태、종괴대소、ER급PR표체상태여환자적5년무병솔화5년생존솔명현상관(P＜0.05).결론 ER급PR가작위예측액하림파결위음성적유선암환자원기생존적중요지표,위유선암치료방안제공삼고의거.
Objective To investigate the correlation of Her-2 expression with the clinicopathological characteristics and prognosis of axillary lymph node-negative breast cancer patients.Methods The clinical data of 278 patients with axillary lymph node-negative breast cancer between 2003 and 2009 admitted in the third affiliated hospital of Zhengzhou University were collected.The clinicopathological characteristics,distant metastasis and survival information were retrospectively analyzed,and then the prognostic influencing factors of breast cancer were further investigated.Results Among the 278 patients with axillary lymph node-negative breast cancer,the level of Her-2 expression was significantly correlated with tumor size,estrogen receptor and progesterone receptor expression levels (P ＜ 0.05).Morever,the menopausal status,tumor size,and the expressions of ER and PR were significantly correlated with five-years disease-free survival rate and five-years overall survival rate (P ＜0.05).Conclusions ER and PR can serve as important indicator of the long-term survival state of patients with breast cancer,and provide reference for making therapy.