CAJ | 학술논문

手术截断小鼠尾末端可诱发长期性的痛觉过敏和吗啡镇痛效应变化.这种长期性的变化可能是由于中枢神经系统的神经可塑性变化引起的(从脊髓背角到皮层).在截尾5周后,小鼠后肢和余下的尾端出现痛敏反应.低剂量吗啡可诱发热板的易化反应.这些可塑性变化能延长至5周,因此小鼠的截尾模型可以用于研究截肢后的中枢性长期性的可塑性变化.
수술절단소서미말단가유발장기성적통각과민화마배진통효응변화.저충장기성적변화가능시유우중추신경계통적신경가소성변화인기적(종척수배각도피층).재절미5주후,소서후지화여하적미단출현통민반응.저제량마배가유발열판적역화반응.저사가소성변화능연장지5주,인차소서적절미모형가이용우연구절지후적중추성장기성적가소성변화.
Amputation of a segment of the tail produced long-lasting changes in nociception and morphine-induced antinociception.Plastic changes in nociceptive transmission may occur at the spinal cord as well as supraspinal structures after tail amputation. Acutehyperalgesia is detected at the remaining part of the tail as well as hindpaw. Morphine induced facilitation of the hot-plate (HP) responseat a low dose and a greater dose of morphine is required to produce complete inhibition of the HP response. Since these effects happen atfive weeks after the surgery, tail amputation may serve as a mouse model for studying long-term plastic changes in central nervous systemafter amputation.