CAJ | 학술논문

目的观察氯诺昔康对腹腔镜阑尾切除术后炎性反应的作用.方法选择ASA级Ⅰ～Ⅱ在联合腰硬麻醉下行腹腔镜阑尾切除术的患者40例,随机分为观察组和对照组,每组20例.观察组麻醉前静脉注射氯诺昔康8 mg(用注射用水2 ml稀释),对照组静脉注射用水2ml.于L2.3间隙穿刺行腰硬联合麻醉,调节阻滞平面到T6节段,术中静脉注射哌替啶、氟哌利多和安定维持镇静.于手术前1小时和术后1天抽取外周静脉血,进行白细胞计数,并测定血中C反应蛋白(CRP)浓度.结果两组患者术后1天的白细胞计数和CRP浓度较术前明显下降(P＜ 0.05)；两组间比较,在术后1天,白细胞计数观察组明显低于对照组(5.4±3.7)比(7.6±3.2)(P＜ 0.05)CRP浓度观察组也明显低于对照组(6.4±3.7)比(9.6±4.1)(P＜0.05).结论麻醉前静脉注射氯诺昔康可减轻腹腔镜阑尾切除术患者术后早期炎性反应.
목적 관찰록낙석강대복강경란미절제술후염성반응적작용.방법 선택ASA급Ⅰ～Ⅱ재연합요경마취하행복강경란미절제술적환자40례,수궤분위관찰조화대조조,매조20례.관찰조마취전정맥주사록낙석강8 mg(용주사용수2 ml희석),대조조정맥주사용수2ml.우L2.3간극천자행요경연합마취,조절조체평면도T6절단,술중정맥주사고체정、불고리다화안정유지진정.우수술전1소시화술후1천추취외주정맥혈,진행백세포계수,병측정혈중C반응단백(CRP)농도.결과 량조환자술후1천적백세포계수화CRP농도교술전명현하강(P＜ 0.05)；량조간비교,재술후1천,백세포계수관찰조명현저우대조조(5.4±3.7)비(7.6±3.2)(P＜ 0.05)CRP농도관찰조야명현저우대조조(6.4±3.7)비(9.6±4.1)(P＜0.05).결론마취전정맥주사록낙석강가감경복강경란미절제술환자술후조기염성반응.
Objective To investigate the effects of lornoxicam on postoperative inflammatory reaction in patients undergoing laparoscopic appendectomy.Methods Sixty ASA Ⅰ - Ⅱ patients undergoing laparoscopic appendectomy were assigned to study group and control group ( 24 for each ).The study group received intravenous loronoxicam of 8 mg diluted with normal saline of 2ml before anesthesia,and the control group received the same volume of normal saline.All the patients were anesthetized with combined spinal and epidural blockage and tranquilized with pethedine,droperidol,and diazepam.Peripheral vein blood were extracted one hour before surgery and one day after operation to measure leukocyte count; the concentration of C reaction protein ( CRP ) was detected.Results Leukocyte count and CRP concentration were markedly decreased ond day after surgery in both groups ( P＜ 0.05 ).Leukocyte count and CRP concentration were significantly lower in the study group than in the control groupt[( 5.4 + 3.7 ) vs.( 7.6 +3.2) and (6.4 ± 3.7) vs.(9.6 ± 4.1 ),P＜ 0.05 for both comparisons].Conclusions Intravenous lornoxicam before anesthesia can suppress inflammatory reaction during early postoperative stage in patients undergoing laparoscopic appendectomy.