中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2011年
7期
589-591
,共3页
杨勇锋%李文强%岳伟华%张红星%宋学勤%于洪岩%张岱%杨鸽%赵晶媛%吕路线
楊勇鋒%李文彊%嶽偉華%張紅星%宋學勤%于洪巖%張岱%楊鴿%趙晶媛%呂路線
양용봉%리문강%악위화%장홍성%송학근%우홍암%장대%양합%조정원%려로선
精神分裂症%Ghrelin GHRL%单核苷酸多态性
精神分裂癥%Ghrelin GHRL%單覈苷痠多態性
정신분렬증%Ghrelin GHRL%단핵감산다태성
Schizophrenia%Ghrelin(GHRL)%Single nucleotide polymorphism
目的 探讨Ghrelin(GHRL)基因单核甘酸多态性与精神分裂症的关联.方法 纳入634例精神分裂症患者和606例健康对照,采用限制性片段长度多态性和聚合酶链反应技术检测GHRL基因4个SNP位点rs696217、rs26802、rs27647和rs26311基因型.结果 GHRL基因4个单核甘酸多态位点基因型和等位基因频率在病例组和对照组中的分布差异均无显著性(基因型频率P值分别为0.649,0.944,0.410,0.826;等位基因频率P值分别为0.773,0.992,0.301,0.723).而病例组与对照组的单体型(rs696217-rs26802--rs27647-rs26311))分析:GAAG、GAGC、GAGC、GCGG、GCGG、TAGC、TAGG单体型频率的差异均存在显著性(P值分别为0.011,0.001,1.76×10-6,9.84×10-10,1.38×10-9,2.12×10-5,2.57×10-6).结论 GHRL基因可能不是精神分裂症的易感基因,但GA单体型可能是精神分裂症的易感因素.
目的 探討Ghrelin(GHRL)基因單覈甘痠多態性與精神分裂癥的關聯.方法 納入634例精神分裂癥患者和606例健康對照,採用限製性片段長度多態性和聚閤酶鏈反應技術檢測GHRL基因4箇SNP位點rs696217、rs26802、rs27647和rs26311基因型.結果 GHRL基因4箇單覈甘痠多態位點基因型和等位基因頻率在病例組和對照組中的分佈差異均無顯著性(基因型頻率P值分彆為0.649,0.944,0.410,0.826;等位基因頻率P值分彆為0.773,0.992,0.301,0.723).而病例組與對照組的單體型(rs696217-rs26802--rs27647-rs26311))分析:GAAG、GAGC、GAGC、GCGG、GCGG、TAGC、TAGG單體型頻率的差異均存在顯著性(P值分彆為0.011,0.001,1.76×10-6,9.84×10-10,1.38×10-9,2.12×10-5,2.57×10-6).結論 GHRL基因可能不是精神分裂癥的易感基因,但GA單體型可能是精神分裂癥的易感因素.
목적 탐토Ghrelin(GHRL)기인단핵감산다태성여정신분렬증적관련.방법 납입634례정신분렬증환자화606례건강대조,채용한제성편단장도다태성화취합매련반응기술검측GHRL기인4개SNP위점rs696217、rs26802、rs27647화rs26311기인형.결과 GHRL기인4개단핵감산다태위점기인형화등위기인빈솔재병례조화대조조중적분포차이균무현저성(기인형빈솔P치분별위0.649,0.944,0.410,0.826;등위기인빈솔P치분별위0.773,0.992,0.301,0.723).이병례조여대조조적단체형(rs696217-rs26802--rs27647-rs26311))분석:GAAG、GAGC、GAGC、GCGG、GCGG、TAGC、TAGG단체형빈솔적차이균존재현저성(P치분별위0.011,0.001,1.76×10-6,9.84×10-10,1.38×10-9,2.12×10-5,2.57×10-6).결론 GHRL기인가능불시정신분렬증적역감기인,단GA단체형가능시정신분렬증적역감인소.
Objective To investigate the potential association of Ghrelin(GHRL)gene polymorphisms susceptible to schizophrenia by case-control study.Methods Six hundred and thirty-four patients,six hundred and six healthy control subjects were recruited.Four SNPs rs696217,rs26802,rs27647 and rs26311 were detected by the polymerase chain reaction-based-restriction fragment length polymorphism analysis.Results No significant differences in genotype or allele frequencies of the four SNPs were observed between schizophrenic patients and healthy controls (Pvalues of genotype frequencies were 0.649,0.944,0.410,0.826;P values of allele frequencies were 0.773,0.992,0.301,0.723).However,seven haplotypes(GAAG,GAGC,GAGG,GCGC,GCGG,TAGC,TAGG)showed significant differences in frequency between schizophrenic and control groups(P values were 0.011,0.001,1.76×10-6,9.84×10-10,1.38×10-9,2.12×10-5,2.57×10-6).Conclusion These data suggest that the GHRL gene may not be associated with susceptibility to schizophrenia in the Chinese Han population.However,the haplotype of GA may be the susceptive factor of schizophrenia.