中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2012年
14期
2130-2131
,共2页
氯氮平%精神分裂症%心电描记术
氯氮平%精神分裂癥%心電描記術
록담평%정신분렬증%심전묘기술
Clozapine%Schizophrenia%Electrocardiography
目的 观察抗精神病药物氯氮平的剂量对心电图异常的影响.方法 对持续服用氯氮平治疗2年以上的81例精神分裂症患者服用不同剂量的氯氮平时的心电图检查结果进行回顾性分析.结果 氯氮平≥200 mg/d有35例患者,其中27例有心电图异常,占77.14％；＜200 mg/d有46例患者,其中24例有心电图异常,占52.17％,两组差异有统计学意义(x2=5.13,P＜0.05)；两组心电图异常均以T波异常占首位,窦性心动过速居第二位.结论 患者心电图的异常改变和氯氮平的剂量存在着一定的关系,并随着用药剂量的增加而增多.
目的 觀察抗精神病藥物氯氮平的劑量對心電圖異常的影響.方法 對持續服用氯氮平治療2年以上的81例精神分裂癥患者服用不同劑量的氯氮平時的心電圖檢查結果進行迴顧性分析.結果 氯氮平≥200 mg/d有35例患者,其中27例有心電圖異常,佔77.14％；＜200 mg/d有46例患者,其中24例有心電圖異常,佔52.17％,兩組差異有統計學意義(x2=5.13,P＜0.05)；兩組心電圖異常均以T波異常佔首位,竇性心動過速居第二位.結論 患者心電圖的異常改變和氯氮平的劑量存在著一定的關繫,併隨著用藥劑量的增加而增多.
목적 관찰항정신병약물록담평적제량대심전도이상적영향.방법 대지속복용록담평치료2년이상적81례정신분렬증환자복용불동제량적록담평시적심전도검사결과진행회고성분석.결과 록담평≥200 mg/d유35례환자,기중27례유심전도이상,점77.14％；＜200 mg/d유46례환자,기중24례유심전도이상,점52.17％,량조차이유통계학의의(x2=5.13,P＜0.05)；량조심전도이상균이T파이상점수위,두성심동과속거제이위.결론 환자심전도적이상개변화록담평적제량존재착일정적관계,병수착용약제량적증가이증다.
Objective To observe the antipsychotic clozapine dose to the influence of the abnormal ecg.Methods The continuous use clozapine 2 years of treatment for 81 cases of schizophrenia patients taken different doses of ecg examination results were retrospectively analyzed.Results ≥200mg/d quartile group 35 examples have 27 cases who had electrocardiogram abnormalities,the abnormal rate was 77.14％,＜ 200mg group 46 patients had 24 cases who had electrocardiogram abnormalities,the abnormal rate was 52.17％,there were significant differences,the two groups was statistically significant(x2 =5.13,P ＜ 0.05),two of which were all with abnormal wave of first,T sinus tachycardia in the second.Conclusion The change with the patient's electrocardiogram dosage had certain relations.Patients with abnormal ecg situation of may increase with drug doses increasing.
