中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2009年
29期
17-20
,共4页
乳腺肿瘤%受体%雌激素%受体%孕激素%受体%Her-2
乳腺腫瘤%受體%雌激素%受體%孕激素%受體%Her-2
유선종류%수체%자격소%수체%잉격소%수체%Her-2
Breast neoplasms%Receptors,estrogen%Receptors,progestins%Receptors,Her-2
目的 比较三阴乳腺癌与非三阴乳腺癌预后的不同及其影响因素.方法 回顾性分析1998年12月至2007年6月收治的684例临床可手术乳腺癌患者的临床资料,其中107例为三阴乳腺癌患者(三阴组),577例为非三阴乳腺癌患者(非三阴组).应用Kaplan-Meier法进行生存分析,组间比较用log-rank检验,多因素分析采用COX比例风险模型.结果 三阴组与非三阴组总的7年生存率分别为51.4%(55/107)及74.2%(428/577),差异有统计学意义(P＜0.01).Her-2表达阳性患者总的7年生存率为53.1%(43/81),与三阴组比较差异无统计学意义(P＞0.05).单因素分析结果显示患者的年龄、月经状态、肿瘤大小、腋窝淋巴结状态及受体状况均为预后影响因素.多因素分析结果表明肿瘤大小、腋窝淋巴结状态及受体状况为预后的独立影响因素.结论 三阴乳腺癌和Her-2表达阳性的乳腺癌患者治疗效果均较差,三阴乳腺癌是一个独立的预后影响因素.
目的 比較三陰乳腺癌與非三陰乳腺癌預後的不同及其影響因素.方法 迴顧性分析1998年12月至2007年6月收治的684例臨床可手術乳腺癌患者的臨床資料,其中107例為三陰乳腺癌患者(三陰組),577例為非三陰乳腺癌患者(非三陰組).應用Kaplan-Meier法進行生存分析,組間比較用log-rank檢驗,多因素分析採用COX比例風險模型.結果 三陰組與非三陰組總的7年生存率分彆為51.4%(55/107)及74.2%(428/577),差異有統計學意義(P＜0.01).Her-2錶達暘性患者總的7年生存率為53.1%(43/81),與三陰組比較差異無統計學意義(P＞0.05).單因素分析結果顯示患者的年齡、月經狀態、腫瘤大小、腋窩淋巴結狀態及受體狀況均為預後影響因素.多因素分析結果錶明腫瘤大小、腋窩淋巴結狀態及受體狀況為預後的獨立影響因素.結論 三陰乳腺癌和Her-2錶達暘性的乳腺癌患者治療效果均較差,三陰乳腺癌是一箇獨立的預後影響因素.
목적 비교삼음유선암여비삼음유선암예후적불동급기영향인소.방법 회고성분석1998년12월지2007년6월수치적684례림상가수술유선암환자적림상자료,기중107례위삼음유선암환자(삼음조),577례위비삼음유선암환자(비삼음조).응용Kaplan-Meier법진행생존분석,조간비교용log-rank검험,다인소분석채용COX비례풍험모형.결과 삼음조여비삼음조총적7년생존솔분별위51.4%(55/107)급74.2%(428/577),차이유통계학의의(P＜0.01).Her-2표체양성환자총적7년생존솔위53.1%(43/81),여삼음조비교차이무통계학의의(P＞0.05).단인소분석결과현시환자적년령、월경상태、종류대소、액와림파결상태급수체상황균위예후영향인소.다인소분석결과표명종류대소、액와림파결상태급수체상황위예후적독립영향인소.결론 삼음유선암화Her-2표체양성적유선암환자치료효과균교차,삼음유선암시일개독립적예후영향인소.
Objective To assess whether survival differed among patients who had triple-negative breast cancers compared with patients who had non-triple-negative breast cancers.Methods The clinicopathologic data of 684 patients with operable breast cancer,who were treated with multimodal therapy from December 1998 to June 2007 were analyzed.Of these patients,107 cases were confirmed to have triple-negative tumor histology(triple-negative group),577 cases were confirmed to have non-triple-negative tumor histology(non-triple-negative group).The 7 years cumulative survival and disease-free survival were analyzed by Kaplan-Meier method and compared by Log-rank test.The prognosis Was analyzed by COX regression model.Results The 7 years overall survival rates for triple-negative group and non-triple-negative group were 51.4%(55/107),74.2%(428/577),respectively,there Was significant difference between the two groups(P＜0.01).However,the 7 years overall survival rates of patients with triple-negative group and those who with Her-2 positive were 51.4%(55/107)and 53.1%(43/81)respectively,there Was no significant difference between them (P＞0.05).Univariate analysis revealed that the factors affecting the disease-free survival included age,menopausal status,tumor size,lymph nodes metastasis,estrogen,progesterone,and Her-2 receptors status.Multivariate analysis showed minor size,lymph nodes metastasis,estrogen,progesterone,and Her-2 receptors status were independent prognostic factors.Conclusions This study has shown a trend towards a poorer outcome for patients with triple-negative breast cancer similarity to patients with Her-2 positive cancers.Triple-negative breast cancer is an independent predictor factor of survival.
