中华临床感染病杂志
中華臨床感染病雜誌
중화림상감염병잡지
CHINESE JOURNAL OF CLINICAL INFECTIOUS DISEASES
2010年
6期
337-339
,共3页
李素华%陈洁%汪洪姣%陈均亚%徐志伟%陈益平
李素華%陳潔%汪洪姣%陳均亞%徐誌偉%陳益平
리소화%진길%왕홍교%진균아%서지위%진익평
手足口病%肠道病毒感染%临床特征%儿童
手足口病%腸道病毒感染%臨床特徵%兒童
수족구병%장도병독감염%림상특정%인동
Hand,foot and mouth disease%Enterovirus infections%Clinical features%Child
目的 分析浙江省温州地区重症手足口病患儿的临床和实验室特征.方法 收集2010年1-5月温州医学院附属儿童医院107例重症手足口病患儿的临床和实验室资料,其中重型97例,危重型10例.随机选取门诊或住院普通手足口病患儿150例作为对照.分析并比较两组患儿的临床特征及实验室检查结果.结果 所有重症患儿均有发热、皮疹和中枢神经系统感染症状,呼吸、消化和心血管系统症状较普通型患儿常见且病情较重.重症患儿外周血白细胞计数明显高于普通组(t=12.72,P＜0.01),且所有危重症患儿均存在高血糖(9.2 mmol/L)和肌钙蛋白异常(0.3～9.0 ng/mL).97例重症患儿脑脊髓液检查WBC升高,平均值为98.5×106/L,以淋巴细胞增高为主.107例重症患儿中,70例(65.4%)患儿EV71阳性,其中10例危重症患儿EV71均为阳性.结论 重症手足口病以EV71感染为主,中枢神经系统、呼吸循环系统及消化系统等多受累,病情严重,临床上应引起重视.
目的 分析浙江省溫州地區重癥手足口病患兒的臨床和實驗室特徵.方法 收集2010年1-5月溫州醫學院附屬兒童醫院107例重癥手足口病患兒的臨床和實驗室資料,其中重型97例,危重型10例.隨機選取門診或住院普通手足口病患兒150例作為對照.分析併比較兩組患兒的臨床特徵及實驗室檢查結果.結果 所有重癥患兒均有髮熱、皮疹和中樞神經繫統感染癥狀,呼吸、消化和心血管繫統癥狀較普通型患兒常見且病情較重.重癥患兒外週血白細胞計數明顯高于普通組(t=12.72,P＜0.01),且所有危重癥患兒均存在高血糖(9.2 mmol/L)和肌鈣蛋白異常(0.3～9.0 ng/mL).97例重癥患兒腦脊髓液檢查WBC升高,平均值為98.5×106/L,以淋巴細胞增高為主.107例重癥患兒中,70例(65.4%)患兒EV71暘性,其中10例危重癥患兒EV71均為暘性.結論 重癥手足口病以EV71感染為主,中樞神經繫統、呼吸循環繫統及消化繫統等多受纍,病情嚴重,臨床上應引起重視.
목적 분석절강성온주지구중증수족구병환인적림상화실험실특정.방법 수집2010년1-5월온주의학원부속인동의원107례중증수족구병환인적림상화실험실자료,기중중형97례,위중형10례.수궤선취문진혹주원보통수족구병환인150례작위대조.분석병비교량조환인적림상특정급실험실검사결과.결과 소유중증환인균유발열、피진화중추신경계통감염증상,호흡、소화화심혈관계통증상교보통형환인상견차병정교중.중증환인외주혈백세포계수명현고우보통조(t=12.72,P＜0.01),차소유위중증환인균존재고혈당(9.2 mmol/L)화기개단백이상(0.3～9.0 ng/mL).97례중증환인뇌척수액검사WBC승고,평균치위98.5×106/L,이림파세포증고위주.107례중증환인중,70례(65.4%)환인EV71양성,기중10례위중증환인EV71균위양성.결론 중증수족구병이EV71감염위주,중추신경계통、호흡순배계통급소화계통등다수루,병정엄중,림상상응인기중시.
Objective To investigate the clinical and laboratory features of severe cases of hand,foot and mouth disease (HFMD) in Wenzhou, Zhejiang Province. Methods Clinical data of 107 children with HFMD, including 97 severe and 10 critical cases treated in Children' s Hospital Affiliated to Wenzhou Medical College during January and May 2010 were retrospectively analyzed. One hundred and fifty children with mild HFMD were also selected as the controls. Clinical features and laboratory results were compared between the two groups. Results Fever, rash and infection in central nervous system were observed in all patients with severe HFMD, and symptoms on respiratory, digestive and cardiovascular systems were more serious than those of mild HFMD cases. White blood cell counts (WBC) were higher in severe group than those in controls (t = 12.72, P ＜0.01). Hyperglycemia (9. 2 mmol/L) and abnormal troponin (0. 3 -9. 0 ng/mL) were presented in all the critical patients. Cerebrospinal fluid WBC counts were raised in 97 severe HFMD patients (98.5 × 106/L for average) with predominance of lymphocytes. Among 107 severe patients, EV71 was positive in 70, including all 10 critical cases. Conclusion Involvement of nervous,respiratory and digestive symptoms is common in severe cases of HFMD, and EV71 is the predominant pathogen.
