中华皮肤科杂志
中華皮膚科雜誌
중화피부과잡지
Chinese Journal of Dermatology
2011年
1期
50-52
,共3页
叶青%陈学军%李建平%曹禾谦
葉青%陳學軍%李建平%曹禾謙
협청%진학군%리건평%조화겸
目的 探讨非梅毒螺旋体抗原血清学试验和梅毒螺旋体抗原血清学试验检测胎传梅毒的价值及其临床实用性.方法 对门诊及住院7800例新生儿用甲苯胺红不加热血清试验(TRUST)做非特异性抗体定量检测,梅毒螺旋体明胶颗粒凝聚集试验(TPPA)做特异性抗体定性检测.统计分析确诊的胎传梅毒患儿初次梅毒血清学试验结果.比较TPPA和TRUST试验的敏感度和特异性.结果 进行血清学筛查的7800例新生儿中,初次梅毒血清学检测TPPA(+)、TRUST(+)60例,其中胎传梅毒患儿15例;初次梅毒血清学检测TPPA(+)、TRUST(-)47例,其中胎传梅毒患儿5例.TRUST试验检测胎传梅毒的敏感率为75%(5/20),特异性为99.41%(7734/7780).TPPA试验检测胎传梅毒的敏感率为100%(20/20),特异性为98.88%(7693/7780).结论 TPPA比TRUST更适用于胎传梅毒的筛查.
目的 探討非梅毒螺鏇體抗原血清學試驗和梅毒螺鏇體抗原血清學試驗檢測胎傳梅毒的價值及其臨床實用性.方法 對門診及住院7800例新生兒用甲苯胺紅不加熱血清試驗(TRUST)做非特異性抗體定量檢測,梅毒螺鏇體明膠顆粒凝聚集試驗(TPPA)做特異性抗體定性檢測.統計分析確診的胎傳梅毒患兒初次梅毒血清學試驗結果.比較TPPA和TRUST試驗的敏感度和特異性.結果 進行血清學篩查的7800例新生兒中,初次梅毒血清學檢測TPPA(+)、TRUST(+)60例,其中胎傳梅毒患兒15例;初次梅毒血清學檢測TPPA(+)、TRUST(-)47例,其中胎傳梅毒患兒5例.TRUST試驗檢測胎傳梅毒的敏感率為75%(5/20),特異性為99.41%(7734/7780).TPPA試驗檢測胎傳梅毒的敏感率為100%(20/20),特異性為98.88%(7693/7780).結論 TPPA比TRUST更適用于胎傳梅毒的篩查.
목적 탐토비매독라선체항원혈청학시험화매독라선체항원혈청학시험검측태전매독적개치급기림상실용성.방법 대문진급주원7800례신생인용갑분알홍불가열혈청시험(TRUST)주비특이성항체정량검측,매독라선체명효과립응취집시험(TPPA)주특이성항체정성검측.통계분석학진적태전매독환인초차매독혈청학시험결과.비교TPPA화TRUST시험적민감도화특이성.결과 진행혈청학사사적7800례신생인중,초차매독혈청학검측TPPA(+)、TRUST(+)60례,기중태전매독환인15례;초차매독혈청학검측TPPA(+)、TRUST(-)47례,기중태전매독환인5례.TRUST시험검측태전매독적민감솔위75%(5/20),특이성위99.41%(7734/7780).TPPA시험검측태전매독적민감솔위100%(20/20),특이성위98.88%(7693/7780).결론 TPPA비TRUST경괄용우태전매독적사사.
Objective To assess the value and clinical applicability of non-treponemal antigen serologic test and Treponema pallidum antigen serologic test in the diagnosis of congenital syphilis. Methods Totally,7800 newborns were collected from the out-patient and in-patient department. Toluidine red unheated serum test (TRUST) was conducted to quantitatively detect non-treponemal antibodies and Treponema pallidum particle agglutination assay (TPPA) to qualitatively detect specific treponemal antibodies in these subjects. The results of first serology test for syphilis were assessed for neonates with confirmed congenital syphilis. The sensitivity and specificity in the diagnosis of congenital syphilis were compared between TPPA and TRUST.Results Of the 7800 newborns undergoing syphilis serology testa, 60 were positive for TPPA and TRUST,including 15 cases of congenital syphilis, 47 were positive for TPPA but negative for TRUST, including 5 cases of congenital syphilis. The sensitivity and specificity were 75% (5/20) and 99.41% (7734/7780) respectively for TRUST in the diagnosis of congenital syphilis, 100% (20/20) and 98.88% (7693/7780) respectively for TPPA. Conclusion TPPA seems more applicable than TRUST to the screening for congenital syphilis.
