CAJ | 학술논문

目的研究原发性皮肤淋巴瘤的临床表现、组织学特点及免疫表型.方法对17例原发性皮肤淋巴瘤病例进行回顾性分析,按照世界卫生组织.欧洲癌症研究与治疗组织(WHO-EORTC)分类标准,结合形态和免疫组化结果对其进行分类.对不同类型的临床病理学特点分别进行观察、总结.结果 17例患者中,男性10例,女性7例.平均年龄为51(16～78)岁.患者均以发现皮肤病就诊.其中T细胞淋巴瘤14例,包括5例原发性皮肤间变性大细胞淋巴瘤,2例蕈样霉菌病,4例皮下脂膜炎样T细胞淋巴瘤及3例原发性皮肤外周T细胞淋巴瘤(其中1例为原发性皮肤侵袭性亲表皮性CD8+细胞毒性T细胞淋巴瘤).B细胞淋巴瘤3例,包括2例原发性皮肤弥漫大B细胞淋巴瘤(腿型)和1例原发性皮肤滤泡中心淋巴瘤(Ⅲ级).结论原发性皮肤淋巴瘤临床表现及病理学特点复杂多样,两者必须紧密结合才能做出正确的诊断.
목적 연구원발성피부림파류적림상표현、조직학특점급면역표형.방법 대17례원발성피부림파류병례진행회고성분석,안조세계위생조직.구주암증연구여치료조직(WHO-EORTC)분류표준,결합형태화면역조화결과대기진행분류.대불동류형적림상병이학특점분별진행관찰、총결.결과 17례환자중,남성10례,녀성7례.평균년령위51(16～78)세.환자균이발현피부병취진.기중T세포림파류14례,포괄5례원발성피부간변성대세포림파류,2례심양매균병,4례피하지막염양T세포림파류급3례원발성피부외주T세포림파류(기중1례위원발성피부침습성친표피성CD8+세포독성T세포림파류).B세포림파류3례,포괄2례원발성피부미만대B세포림파류(퇴형)화1례원발성피부려포중심림파류(Ⅲ급).결론 원발성피부림파류림상표현급병이학특점복잡다양,량자필수긴밀결합재능주출정학적진단.
Objective To study the clinical, histopathological and immunohistochemistric features of different types of primary cutaneous lymphomas.Methods 17 cases of primary cutaneous lymphomas were ret-rospectively reviewed.All cases were classified according to the WHO-EORTC(World Health Organization-Eu-ropean Organization for Research and Treatment of Cancer) classification system combined with morphology and immunobistochemistry.The clinicopathological features of each type were observed and summarized.Results Among the 17 cases, male were 10, female were 7.The average age was 51 years old (from 16 to 78).All pa-tients visited the doctor for skin diseases 14 cases were T-cell lymphoma including 5 cases of primary cutaneous anaplastic large cell lymphuma, 2 cases of mycosis fungoides, 4 cases of subcutaneous panniculitis-like T-cell lymphoma, and 3 cases of primary cutaneous peripheral T- cell lymphomas (including 1 primary cutaneous ag-gressive epidermotropic CD8+ cytotoxic T-cell lymphoma).3 cases were B-cell lymphoma including 2 diffuse large B-cell lymphoma, leg-type and 1 primary cutaneous follicle center lymphoma.Conclusion The clinical behaviors and pathological characteristics of primary cutaneous lymphomas were complicated and variant.Nei-ther of them could be neglected in the diagnosis.