CAJ | 학술논문

热休克蛋白(HSP)是由Ritossa从经受热刺激后的果蝇唾液腺中发现的,因此取名HSP.但随着后来的大量研究发现,HSP是一切生物体在许多应激状态下(如高温、重金属、缺氧、乙醇、病毒及细菌感染等)合成增加的一种在进化上高度保守的细胞应激蛋白.HSP作为分子伴侣在蛋白质的折叠、稳定性、合成等方面发挥重要作用.晶状体混浊即白内障,是世界上最常见的致盲原因之一.大量的研究表明,白内障的发生与自由基的产生、氧化损伤、晶状体蛋白比例改变及晶状体上皮细胞的凋亡有直接关系.近年来的研究表明,晶状体能表达一系列的HSP,它们对维持晶状体的稳定和透明起到关键作用.本文就HSP与白内障的发生研究现状作一综述.
열휴극단백(HSP)시유Ritossa종경수열자격후적과승타액선중발현적,인차취명HSP.단수착후래적대량연구발현,HSP시일절생물체재허다응격상태하(여고온、중금속、결양、을순、병독급세균감염등)합성증가적일충재진화상고도보수적세포응격단백.HSP작위분자반려재단백질적절첩、은정성、합성등방면발휘중요작용.정상체혼탁즉백내장,시세계상최상견적치맹원인지일.대량적연구표명,백내장적발생여자유기적산생、양화손상、정상체단백비례개변급정상체상피세포적조망유직접관계.근년래적연구표명,정상체능표체일계렬적HSP,타문대유지정상체적은정화투명기도관건작용.본문취HSP여백내장적발생연구현상작일종술.
The hot shock proteins(HSP)were discovered by Ritossa in the fruit fly salivary gland after heat stimulation,giving the name HSP.In following comprehansive studies,it was recovered that HSP was a group of highly conservative cell stress proteins in all organisms.HSP are expressed under many stress conditions,e.g.in the presence of high temperature,heavy metal,oxygen deficit,ethyl alcohol and viral or bacteriae infections,etc.HSP,as the molecular companion,play a vital role in the folding,stability and synthesis of the protein.The lens opacification(cataract)is one of most common causes of blindness in the world.Various studies indicate that the occurrence of cataract is directly related to free radical production,oxidized damage,changes of the proportion of lens protein and apeptnsis of lens capsule epithelial cells,etc.Recent studies indicated that the lens expresses a series of HSP.They play a key role in maintaining the stability and transparency of the lens.This article is a summary of the relationship between the HSP and the occurrence of cataract.