中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2010年
9期
12-13,16
,共3页
巴洛沙星%多索茶碱%高效液相色谱%药动学
巴洛沙星%多索茶堿%高效液相色譜%藥動學
파락사성%다색다감%고효액상색보%약동학
Balofloxacin%Doxofylline%HPLC%Pharmacokinetics
目的 研究兔体内巴洛沙星对多索茶碱的药动学影响.方法 采用高效液相色谱法测定多索茶碱单用及与巴罗沙星合用后不同时间兔体内多索茶碱的血清浓度,以3p97药动学软件对药-时数据进行处理,并进行统计学分析.结果 主要药动学参数如下:多索茶碱单用:T1/2α (11.3±1.7),T1/2β(87±10), CL(s)(0.033±0.005),V(C)(0.96±0.12), AUC0-T(988±137);与巴罗沙星合用:T1/2α (12.7±2.6), T1/2β(90±13), CL(s)(0.032±0.005), V(C)(0.99±0.18), AUC0-T(1029±137).结论 多索茶碱的药动学符合一级动力学消除,二室开放模型,兔体内两药合用时,巴洛沙星对多索茶碱的药动学无显著影响,但会延缓多索茶碱的代谢产物茶碱的消除.
目的 研究兔體內巴洛沙星對多索茶堿的藥動學影響.方法 採用高效液相色譜法測定多索茶堿單用及與巴囉沙星閤用後不同時間兔體內多索茶堿的血清濃度,以3p97藥動學軟件對藥-時數據進行處理,併進行統計學分析.結果 主要藥動學參數如下:多索茶堿單用:T1/2α (11.3±1.7),T1/2β(87±10), CL(s)(0.033±0.005),V(C)(0.96±0.12), AUC0-T(988±137);與巴囉沙星閤用:T1/2α (12.7±2.6), T1/2β(90±13), CL(s)(0.032±0.005), V(C)(0.99±0.18), AUC0-T(1029±137).結論 多索茶堿的藥動學符閤一級動力學消除,二室開放模型,兔體內兩藥閤用時,巴洛沙星對多索茶堿的藥動學無顯著影響,但會延緩多索茶堿的代謝產物茶堿的消除.
목적 연구토체내파락사성대다색다감적약동학영향.방법 채용고효액상색보법측정다색다감단용급여파라사성합용후불동시간토체내다색다감적혈청농도,이3p97약동학연건대약-시수거진행처리,병진행통계학분석.결과 주요약동학삼수여하:다색다감단용:T1/2α (11.3±1.7),T1/2β(87±10), CL(s)(0.033±0.005),V(C)(0.96±0.12), AUC0-T(988±137);여파라사성합용:T1/2α (12.7±2.6), T1/2β(90±13), CL(s)(0.032±0.005), V(C)(0.99±0.18), AUC0-T(1029±137).결론 다색다감적약동학부합일급동역학소제,이실개방모형,토체내량약합용시,파락사성대다색다감적약동학무현저영향,단회연완다색다감적대사산물다감적소제.
Objective To investigate the effects of balofloxacin in rabbits on pharmacokinetics of doxofylline.Methods After single-use of doxofylline and combination with balofloxacin, the concentration of doxofylline in serum were measured by high-performance liquid chromatography(HPLC).The concentration-time data were accessed by 3p97 pharmacokinetic program,and analyzed by statistical methods. Results The pharmacokinetic parameters were single-use of doxofylline, T1/2α(11.3±1.7),T1/2β(87±10),CL(s)(0.033±0.005),V(C)(0.96±0.12),AUC0-T(988±137). Doxotylline in comlination with balofloxacin, T1/2α(12.7±2.6),T1/2β(90±14),CL(s)(0.032±0.005),V(c)(0.99±0.18),AUC0-T(1029±127).Conclusions The pharmacokinetic of doxofylline is correspond with first order kinetics elimination and two compartment open model.Balofloxacin has no effect on the pharmacokinetics of doxofylline,but can postpone the elimination of theophylline,which is the metabolic products of doxofylline.
