中华消化杂志
中華消化雜誌
중화소화잡지
Chinese Journal of Digestion
2009年
7期
433-436
,共4页
郭晓钟%王迪%邵晓冬%赵佳军%李宏宇%崔忠敏%刘峰
郭曉鐘%王迪%邵曉鼕%趙佳軍%李宏宇%崔忠敏%劉峰
곽효종%왕적%소효동%조가군%리굉우%최충민%류봉
骨髓干细胞移植%移植,自体%肝硬化
骨髓榦細胞移植%移植,自體%肝硬化
골수간세포이식%이식,자체%간경화
Hcmatopoietic stem cell transplantation%Transplantation,autologous%Liver cirrhosis
目的 分析自体骨髓干细胞移植对肝硬化患者的治疗作用.方法 选择失代偿期肝硬化患者78例,其中肝炎肝硬化56例、酒精性肝病21例、血吸虫性肝硬化1例,年龄26～67岁.从患者髂后上棘抽取骨髓,体外分离纯化骨髓源性干细胞,通过肝动脉置管移植入肝脏,在移植后2、4、8周复查肝脏功能,观察实验室指标改善、Child-Turcotte-Pugh分数变化及不良反应情况.结果 移植后第4周,患者血浆白蛋白由(32.91±5.58)g/L升至(38.324±6.45)g/L,丙氨酸转氨酶由术前(96.92±83.91)U/L降至(73.48±18.46)U/L(P<0.01).凝血酶原时间从移植前的(16.66±3.91)s逐渐下降至移植后的(15.52±3.35)s,纤维蛋白原从(2.22±0.88)g/L逐渐升高至(2.58±0.88)g/L.干细胞移植术后患者临床症状明显改善,其中食欲改善、体力好转72例(92.3%),腹水减少或消失及下肢浮肿减轻70例(89.7%),腹胀减轻68例(87.2%).近期未发生与干细胞移植相关的并发症.结论 骨髓干细胞移植是治疗失代偿期肝硬化患者安全、有效的方法.
目的 分析自體骨髓榦細胞移植對肝硬化患者的治療作用.方法 選擇失代償期肝硬化患者78例,其中肝炎肝硬化56例、酒精性肝病21例、血吸蟲性肝硬化1例,年齡26～67歲.從患者髂後上棘抽取骨髓,體外分離純化骨髓源性榦細胞,通過肝動脈置管移植入肝髒,在移植後2、4、8週複查肝髒功能,觀察實驗室指標改善、Child-Turcotte-Pugh分數變化及不良反應情況.結果 移植後第4週,患者血漿白蛋白由(32.91±5.58)g/L升至(38.324±6.45)g/L,丙氨痠轉氨酶由術前(96.92±83.91)U/L降至(73.48±18.46)U/L(P<0.01).凝血酶原時間從移植前的(16.66±3.91)s逐漸下降至移植後的(15.52±3.35)s,纖維蛋白原從(2.22±0.88)g/L逐漸升高至(2.58±0.88)g/L.榦細胞移植術後患者臨床癥狀明顯改善,其中食欲改善、體力好轉72例(92.3%),腹水減少或消失及下肢浮腫減輕70例(89.7%),腹脹減輕68例(87.2%).近期未髮生與榦細胞移植相關的併髮癥.結論 骨髓榦細胞移植是治療失代償期肝硬化患者安全、有效的方法.
목적 분석자체골수간세포이식대간경화환자적치료작용.방법 선택실대상기간경화환자78례,기중간염간경화56례、주정성간병21례、혈흡충성간경화1례,년령26～67세.종환자가후상극추취골수,체외분리순화골수원성간세포,통과간동맥치관이식입간장,재이식후2、4、8주복사간장공능,관찰실험실지표개선、Child-Turcotte-Pugh분수변화급불량반응정황.결과 이식후제4주,환자혈장백단백유(32.91±5.58)g/L승지(38.324±6.45)g/L,병안산전안매유술전(96.92±83.91)U/L강지(73.48±18.46)U/L(P<0.01).응혈매원시간종이식전적(16.66±3.91)s축점하강지이식후적(15.52±3.35)s,섬유단백원종(2.22±0.88)g/L축점승고지(2.58±0.88)g/L.간세포이식술후환자림상증상명현개선,기중식욕개선、체력호전72례(92.3%),복수감소혹소실급하지부종감경70례(89.7%),복창감경68례(87.2%).근기미발생여간세포이식상관적병발증.결론 골수간세포이식시치료실대상기간경화환자안전、유효적방법.
Objective To analyze the effect of autologous bone marrow stem cells transplantation in treatment of patients with decompensated cirrhosis. Methodls Seventy-eight patients (aged from 26 to 67) with decompensated cirrhosis, including 56 with hepatitis B, 21 with alcoholic cirrhosis and 1 with schistosomial cirrhosis, were included. Bone marrow was aspirated from poster superior spine. After isolation and purification, the stem cells were transplanted into liver via hepatic artery. The liver function, laboratory parameters and Child-Tureotte-Pugh scores were evaluated in 2,4 and 8 weeks after transplantation. Results At the 4th week after transplantation, the level of albumin was increased obviously from (32.9±5.58) g/L to (38.32±6.45) g/L,whereas the alanine aminotransferase was decreased from (96.92±83.91) U/L to (73.48±18.46)U/L. It was revealed that the prothrombin time was decreased from (16.66±3.91) s to (15.52±3.35) s and fibronegen increased from (2. 22 ± 0. 88) g/L to (2. 58±0. 88) g/L. After transplantation, appetite was improved in 72 cases (92.3%), ascites was decreased in 70 cases (89.7%) and abdomen distention was ameliorated in 68 cases (87.2%). There was no complications related to the transplantation. Conclusion Transplantation of autologous bone marrow stem cells is a safe and effective method in treatment of patients with decompensated cirrhosis.
