中华皮肤科杂志
中華皮膚科雜誌
중화피부과잡지
Chinese Journal of Dermatology
2010年
7期
467-470
,共4页
辛崇美%徐秀莲%李阿梅%姜袆群%陈浩%曾学思%孙建方
辛崇美%徐秀蓮%李阿梅%薑袆群%陳浩%曾學思%孫建方
신숭미%서수련%리아매%강위군%진호%증학사%손건방
黑色素瘤%痣%发育异常痣综合征%痣%上皮样和梭形细胞%胰岛素样生长因子结合蛋白质3
黑色素瘤%痣%髮育異常痣綜閤徵%痣%上皮樣和梭形細胞%胰島素樣生長因子結閤蛋白質3
흑색소류%지%발육이상지종합정%지%상피양화사형세포%이도소양생장인자결합단백질3
Melanoma%Nevus%Dysplastic nevus syndrome%Nevus,epithelioid and spindle cell%Insulinlike growth factor binding protein 3
目的 探讨胰岛素样生长因子Ⅱ mRNA结合蛋白3(IMP3)在良性痣及黑素瘤组织中的表达,及其在恶性黑素瘤进展及诊断中的作用.方法 用IMP3抗体对28例恶性黑素瘤、8例Spitz痣、6例发育不良性痣和25例良性痣患者的标本组织进行免疫组化研究.结果 28例恶性黑素瘤组织标本中23例IMP3阳性,8例Spitz痣中4例阳性,6例发育不良性痣中2例阳性,25例良性痣均不表达.IMP3在黑素瘤中的表达明显高于Spitz痣及发育不良性痣(P<0.05),侵袭性黑素瘤表达明显高于原位黑素瘤(P<0.01).结论 IMP3可能是良性痣发展至恶性黑素瘤的一个生物学标志,在鉴别黑素瘤和良性痣之间存在一定的价值.
目的 探討胰島素樣生長因子Ⅱ mRNA結閤蛋白3(IMP3)在良性痣及黑素瘤組織中的錶達,及其在噁性黑素瘤進展及診斷中的作用.方法 用IMP3抗體對28例噁性黑素瘤、8例Spitz痣、6例髮育不良性痣和25例良性痣患者的標本組織進行免疫組化研究.結果 28例噁性黑素瘤組織標本中23例IMP3暘性,8例Spitz痣中4例暘性,6例髮育不良性痣中2例暘性,25例良性痣均不錶達.IMP3在黑素瘤中的錶達明顯高于Spitz痣及髮育不良性痣(P<0.05),侵襲性黑素瘤錶達明顯高于原位黑素瘤(P<0.01).結論 IMP3可能是良性痣髮展至噁性黑素瘤的一箇生物學標誌,在鑒彆黑素瘤和良性痣之間存在一定的價值.
목적 탐토이도소양생장인자Ⅱ mRNA결합단백3(IMP3)재량성지급흑소류조직중적표체,급기재악성흑소류진전급진단중적작용.방법 용IMP3항체대28례악성흑소류、8례Spitz지、6례발육불량성지화25례량성지환자적표본조직진행면역조화연구.결과 28례악성흑소류조직표본중23례IMP3양성,8례Spitz지중4례양성,6례발육불량성지중2례양성,25례량성지균불표체.IMP3재흑소류중적표체명현고우Spitz지급발육불량성지(P<0.05),침습성흑소류표체명현고우원위흑소류(P<0.01).결론 IMP3가능시량성지발전지악성흑소류적일개생물학표지,재감별흑소류화량성지지간존재일정적개치.
Objective To investigate the expression of insulin-like growth factor-Ⅱ(IGF-Ⅱ) mRNAbinding protein-3 (IMP3) in tissue of benign nevi and malignant melanoma,and to evaluate the role of IMP3 in the development and diagnosis of malignant melanoma.Methods Immunohistochemistry was performed to measure the expression of IMP3 in tissue samples from 28 cases of malignant melanoma,8 Spitz nevi,6 dysplastic nevi and 25 benign nevi.Results Immunohistochemically,IMP3 was observed in 23 of 28 melanoma samples,4 of 8 Spitz nevus samples and 2 of 6 dysplastic nevus samples,but not in benign nevus samples.The expression level of IMP3 wag significantly higher in tissue of melanoma than in that of Spitz nevi and dysplastic nevi (both P<0.05),also higher in tissue of aggressive melanoma than that of melanoma in situ(P<0.01).Conclusions IMP3 seems to be a biomarker for the progression of benign nevi to malignant melanoma,and may be utilized to distinguish melanoma from benign nevi.
