中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2012年
1期
26-28
,共3页
苏静%叶菲%李志勇%杨刚毅%朱伟%李伶%瞿文娟%吴丹冬%张志红
囌靜%葉菲%李誌勇%楊剛毅%硃偉%李伶%瞿文娟%吳丹鼕%張誌紅
소정%협비%리지용%양강의%주위%리령%구문연%오단동%장지홍
Nesfatin-1%胰岛素抵抗%糖调节受损%糖尿病,2型
Nesfatin-1%胰島素牴抗%糖調節受損%糖尿病,2型
Nesfatin-1%이도소저항%당조절수손%당뇨병,2형
Nesfatin-1%Insulin resistance%Impaired glucose regulation%Diabetes mellitus,type 2
采用酶联免疫法测定了初诊2型糖尿病患者、糖调节受损(IGR)患者、正常糖耐量(NGT)者血浆nesfatin-1水平.结果显示,2型糖尿病和IGR组血浆nesfatin-1水平明显高于NGT组[(1.91±0.79和1.80±0.80对1.41±0.58)μg/L,P＜0.01].血浆nesfatin-1水平与体重指数(BMI)、空腹血糖、空腹胰岛素、HbA1C、稳态模型评估的胰岛素抵抗指数(HOMA-IR)呈明显正相关(P＜0.05或P＜O.01).多元回归分析结果表明HOMA-IR和BMI分别是影响血浆nesfatin-1水平的独立相关因素(均P＜0.01).提示血浆nesfatin-1可能参与了胰岛素抵抗和2型糖尿病的发生和发展.
採用酶聯免疫法測定瞭初診2型糖尿病患者、糖調節受損(IGR)患者、正常糖耐量(NGT)者血漿nesfatin-1水平.結果顯示,2型糖尿病和IGR組血漿nesfatin-1水平明顯高于NGT組[(1.91±0.79和1.80±0.80對1.41±0.58)μg/L,P＜0.01].血漿nesfatin-1水平與體重指數(BMI)、空腹血糖、空腹胰島素、HbA1C、穩態模型評估的胰島素牴抗指數(HOMA-IR)呈明顯正相關(P＜0.05或P＜O.01).多元迴歸分析結果錶明HOMA-IR和BMI分彆是影響血漿nesfatin-1水平的獨立相關因素(均P＜0.01).提示血漿nesfatin-1可能參與瞭胰島素牴抗和2型糖尿病的髮生和髮展.
채용매련면역법측정료초진2형당뇨병환자、당조절수손(IGR)환자、정상당내량(NGT)자혈장nesfatin-1수평.결과현시,2형당뇨병화IGR조혈장nesfatin-1수평명현고우NGT조[(1.91±0.79화1.80±0.80대1.41±0.58)μg/L,P＜0.01].혈장nesfatin-1수평여체중지수(BMI)、공복혈당、공복이도소、HbA1C、은태모형평고적이도소저항지수(HOMA-IR)정명현정상관(P＜0.05혹P＜O.01).다원회귀분석결과표명HOMA-IR화BMI분별시영향혈장nesfatin-1수평적독립상관인소(균P＜0.01).제시혈장nesfatin-1가능삼여료이도소저항화2형당뇨병적발생화발전.
Plasma nesfatin-1 levels were assayed by ELISA in patients with impaired glucose regulation (IGR),type 2 diabetes mellitus( T2DM ),and healthy subjects with normal glucose tolerance( control group).The results showed that plasma nesfatin-1 levels in IGR and T2DM groups were significantly higher than that in control group [ ( 1.91 ±0.79 and 1.80±0.80 vs 1.41 ±0.58) μg/L,P＜0.01 ].Plasma nesfatin-1 levels were positively correlated with body mass index(BMI),HbA1c,waist hip ratio,fasting plasma glucose,fasting insulin,and homoestasis model assessment insulin resistant index( HOMA-IR,P＜0.05 or P＜0.01 ).Multiple regression analysis showed that BMI and HOMA-IR were independent related factors in influencing plasma nesfatin-1 levels (both P＜0.01 ).These results suggest that nesfatin-1 may partially contribute to the pathogenesis of insulin resistance and T2DM.
