中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2011年
10期
1030-1034
,共5页
袁英%常富业%黄曼维%宋昕%孙莹%赖杰%李云超%李长新%原向芝%胡秋莹
袁英%常富業%黃曼維%宋昕%孫瑩%賴傑%李雲超%李長新%原嚮芝%鬍鞦瑩
원영%상부업%황만유%송흔%손형%뢰걸%리운초%리장신%원향지%호추형
颈动脉粥样硬化%颈动脉粥样硬化斑块%多重危险因素%总体危险因素%心血管病
頸動脈粥樣硬化%頸動脈粥樣硬化斑塊%多重危險因素%總體危險因素%心血管病
경동맥죽양경화%경동맥죽양경화반괴%다중위험인소%총체위험인소%심혈관병
Carotid atherosclerosis%Carotid atherosclerosis plaque%Multiple risk factors%General risk factors%Angiocardiopathy
目的 探讨颈动脉粥样硬化斑块与多重心血管病危险因素的关系,评估危险因素对亚临床型靶器官损害,减少心血管病总体危险因素.方法 选择2007年5月至2009年5月在我院门诊及病房住院的426例患者给予颈动脉彩色超声检查,根据检查结果分为颈动脉粥样硬化斑块组284例,颈动脉无粥样硬化斑块斑块组142例患者,分别记录年龄、吸烟、体重指数(BMI)、高血压、糖尿病、高脂血症病史.实验室检测血浆总胆固醇(TC)、低密度脂蛋白胆固醇( LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、脂蛋白(a)[LP(a)]、载脂蛋白( ApoA1)、载脂蛋白(ApoB)、超高敏C-反应蛋白(hsCRP)、同型半胱氨酸(HCY)、微量白蛋白尿(MAU)、血尿酸(UA)等,将自变量及单变量数据进行统计学处理,找出致颈动脉粥样硬化斑块的危险因素,并对结果进行分析.结果 年龄、饮酒与颈总动脉内中膜(IMT)增厚相关(P<0.001).超重、糖尿病、LP(a)增高、高脂血症、年龄、MAU、HCY可独立预测颈动脉粥样硬化及斑块形成(x2 =71.35、38.45、t =3.26、x2=37.23、t=118.51、6.723、3.17,P均<0.05)危险因素个数聚集的多寡与IMT、颈动脉粥样硬化斑块独立相关(P =0.0001).结论 年龄、饮酒、超重、糖尿病、LP(a)增高、高脂血症、MAU、HCY是预测颈动脉粥样硬化及斑块形成的危险因素,并具有多重、聚集的特点,危险因素的个数越多,危险性越大.
目的 探討頸動脈粥樣硬化斑塊與多重心血管病危險因素的關繫,評估危險因素對亞臨床型靶器官損害,減少心血管病總體危險因素.方法 選擇2007年5月至2009年5月在我院門診及病房住院的426例患者給予頸動脈綵色超聲檢查,根據檢查結果分為頸動脈粥樣硬化斑塊組284例,頸動脈無粥樣硬化斑塊斑塊組142例患者,分彆記錄年齡、吸煙、體重指數(BMI)、高血壓、糖尿病、高脂血癥病史.實驗室檢測血漿總膽固醇(TC)、低密度脂蛋白膽固醇( LDL-C)、高密度脂蛋白膽固醇(HDL-C)、甘油三酯(TG)、脂蛋白(a)[LP(a)]、載脂蛋白( ApoA1)、載脂蛋白(ApoB)、超高敏C-反應蛋白(hsCRP)、同型半胱氨痠(HCY)、微量白蛋白尿(MAU)、血尿痠(UA)等,將自變量及單變量數據進行統計學處理,找齣緻頸動脈粥樣硬化斑塊的危險因素,併對結果進行分析.結果 年齡、飲酒與頸總動脈內中膜(IMT)增厚相關(P<0.001).超重、糖尿病、LP(a)增高、高脂血癥、年齡、MAU、HCY可獨立預測頸動脈粥樣硬化及斑塊形成(x2 =71.35、38.45、t =3.26、x2=37.23、t=118.51、6.723、3.17,P均<0.05)危險因素箇數聚集的多寡與IMT、頸動脈粥樣硬化斑塊獨立相關(P =0.0001).結論 年齡、飲酒、超重、糖尿病、LP(a)增高、高脂血癥、MAU、HCY是預測頸動脈粥樣硬化及斑塊形成的危險因素,併具有多重、聚集的特點,危險因素的箇數越多,危險性越大.
목적 탐토경동맥죽양경화반괴여다중심혈관병위험인소적관계,평고위험인소대아림상형파기관손해,감소심혈관병총체위험인소.방법 선택2007년5월지2009년5월재아원문진급병방주원적426례환자급여경동맥채색초성검사,근거검사결과분위경동맥죽양경화반괴조284례,경동맥무죽양경화반괴반괴조142례환자,분별기록년령、흡연、체중지수(BMI)、고혈압、당뇨병、고지혈증병사.실험실검측혈장총담고순(TC)、저밀도지단백담고순( LDL-C)、고밀도지단백담고순(HDL-C)、감유삼지(TG)、지단백(a)[LP(a)]、재지단백( ApoA1)、재지단백(ApoB)、초고민C-반응단백(hsCRP)、동형반광안산(HCY)、미량백단백뇨(MAU)、혈뇨산(UA)등,장자변량급단변량수거진행통계학처리,조출치경동맥죽양경화반괴적위험인소,병대결과진행분석.결과 년령、음주여경총동맥내중막(IMT)증후상관(P<0.001).초중、당뇨병、LP(a)증고、고지혈증、년령、MAU、HCY가독립예측경동맥죽양경화급반괴형성(x2 =71.35、38.45、t =3.26、x2=37.23、t=118.51、6.723、3.17,P균<0.05)위험인소개수취집적다과여IMT、경동맥죽양경화반괴독립상관(P =0.0001).결론 년령、음주、초중、당뇨병、LP(a)증고、고지혈증、MAU、HCY시예측경동맥죽양경화급반괴형성적위험인소,병구유다중、취집적특점,위험인소적개수월다,위험성월대.
Objective To investigate the relationship between carotid atherosclerotic plaque and multiple risk factors of angiocardiopathy,and to evaluate the injuries caused by different risk factors to subclinical target organ to control the general risk factors of angiocardiopathy.Methods Four hundred and twenty six outpatients and impatients,treated in our hospital from May 2007 to May 2009 with the results of color ultrasonic examination,were divided into carotid atherosclerotic plaque group(284 cases) and no carotid atherosclerotic plaque group( 142 cases).The clinical information including their age,body mass index,smoking condition,past medical history such as hypertension,diabetes mellitus and hyperlipoidemia were recorded,and the levels of total cholesterol(T C),high density lipoprotein cholesterol( HDL-C),low density lipoprotein cholesterol(LDL-C),triglyceride (TG),lipoprotein ( a ) ( LP (a) ),apolipoprotein A - 1 ( Apo A 1 ),apolipoprotein B ( Apo B ),highsensitivity C-reactive protein( hs-CRP),homocysteine ( HCY),microalbuminuria( MAU ) and uricacid(UA) were determined by lab tests.The independent variable and univariable data were processed and analyzed statistically to find out the risk factors of carotid atherosclerotic plaque.Results Age and drinking were significantly correlated with the carotid intima-media wall thickening(IMT) (P < 0.001 ).Overweight,diabetes mellitus,increased LP (a),hyperlipoidemia,age,increased MAU and HCY could independently predict carotid atherosclerosis and plaque formation ( x2 =71.35,38.45,t =3.26,x2 =37.23,t =118.51,6.723 and 3.17respectively,Ps < 0.05 ).The aggregated number of the risk factors was correlated to IMT and carotid atherosclerotic plaque ( P =0.0001 ).Conclusion Age,drinking,overweight,diabetes mellitus,increased LP (a),hyperlipoidemia,MAU and HCY are risk factors of carotid atherosclerosis and plaque formation,and the contribution of each factor can multiply and overlap,more risk factors means greater risk.