中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2010年
5期
96-97
,共2页
孙彦青%韩崇伟%王刚平%王忠英%周玉美
孫彥青%韓崇偉%王剛平%王忠英%週玉美
손언청%한숭위%왕강평%왕충영%주옥미
葡萄胎%细胞黏附分子%基质金属蛋白酶%人绒毛膜促性腺激素
葡萄胎%細胞黏附分子%基質金屬蛋白酶%人絨毛膜促性腺激素
포도태%세포점부분자%기질금속단백매%인융모막촉성선격소
Hydatidiform mole%Cell adhesion molecule CD44V6%Matrix metalloproteinase-9%HCG
目的 探讨CD44V6、MMP-9及HCG的表达对完全性葡萄胎恶变的预测价值.方法 采用免疫组化SP法检测53例葡萄胎组织中CD44V6、MMP-9的表达,采用化学发光法测定葡萄胎患者血人绒毛膜促性腺激素HCG水平,分析三者其对完全性葡萄胎恶变的预测价值.结果 葡萄胎恶变9例,未恶变44例;CD44V6、MMP-9在恶变组中的阳性表达(77.8%、66.7%)明显高于未恶变组(31.8%、43.2%),P＜0.05;恶变组4例血HCG持续阳性和5例降而复升.结论 CD44V6和MMP-9在葡萄胎恶变过程中起重要作用,联合检测CD44V6、MMP-9及HCG有助于判断葡萄胎的生物学行为和预后.
目的 探討CD44V6、MMP-9及HCG的錶達對完全性葡萄胎噁變的預測價值.方法 採用免疫組化SP法檢測53例葡萄胎組織中CD44V6、MMP-9的錶達,採用化學髮光法測定葡萄胎患者血人絨毛膜促性腺激素HCG水平,分析三者其對完全性葡萄胎噁變的預測價值.結果 葡萄胎噁變9例,未噁變44例;CD44V6、MMP-9在噁變組中的暘性錶達(77.8%、66.7%)明顯高于未噁變組(31.8%、43.2%),P＜0.05;噁變組4例血HCG持續暘性和5例降而複升.結論 CD44V6和MMP-9在葡萄胎噁變過程中起重要作用,聯閤檢測CD44V6、MMP-9及HCG有助于判斷葡萄胎的生物學行為和預後.
목적 탐토CD44V6、MMP-9급HCG적표체대완전성포도태악변적예측개치.방법 채용면역조화SP법검측53례포도태조직중CD44V6、MMP-9적표체,채용화학발광법측정포도태환자혈인융모막촉성선격소HCG수평,분석삼자기대완전성포도태악변적예측개치.결과 포도태악변9례,미악변44례;CD44V6、MMP-9재악변조중적양성표체(77.8%、66.7%)명현고우미악변조(31.8%、43.2%),P＜0.05;악변조4례혈HCG지속양성화5례강이복승.결론 CD44V6화MMP-9재포도태악변과정중기중요작용,연합검측CD44V6、MMP-9급HCG유조우판단포도태적생물학행위화예후.
Objective To investigate the prognostic value of CD44V6,MMP-9 and HCG in mallgnant in transformation of hydatidiform mole.Methods The expressions of CD44V6 and MMP-9 was detected by S-P method and the serum HCG was detected with CLIA method in 53 cases of hydatidiform mole and the relationship of the expression was analyzed.Results There were 9 cases malignant transforming hydatidiform mole and 44 eases of non-malignant transforming hydatidiform mole.The expression of CD44V6 and MMP-9 of malignant transforming mole(77.8% and 66.7%)significantly higher than that of non-malignant transforming group(31.8%and 43.2%) (P ＜ 0.05).Conclusion CD44v6 and MMP-9 play important roles in the process of transformation of hydatidiform mole.The combined detection of CD44V6,MMP-9 and HCG can help to prodict biological behaviors and prognosis of hydatidiform mole.
