国际生物医学工程杂志
國際生物醫學工程雜誌
국제생물의학공정잡지
INTERNATIONAL JOURNAL OF BIOMEDICAL ENGINEERING
2012年
2期
86-89,后插3
,共5页
新型螺旋电极%视神经%选择性刺激%激活函数
新型螺鏇電極%視神經%選擇性刺激%激活函數
신형라선전겁%시신경%선택성자격%격활함수
New helix electrode%Optic nerve%Selective stimulation%Activating function
目的 电刺激中枢神经系统已用于治疗一些神经病、精神病和感觉障碍.尽管在一些应用里相当成功,但现有的刺激技术不能精确地控制激活靶向神经元.提出一种形状自适应的新型螺旋电极,实现选择性刺激视神经.方法 应用COMSOL Multiphysics建立视神经和新型螺旋电极的几何模型；新型电极由起支撑和绝缘隔离作用的硅橡胶螺旋支架和嵌入支架内的铂金触点组成.引入激活函数来表征刺激效果,应用COMSOL仿真分析新型螺旋电极对视神经纤维选择性刺激的能力,并考虑电极触点位置的变化对选择性的影响.结果 假定激活函数的归一化阈值为0.1 V/m2,新型螺旋电极和传统袖套电极激活函数大于阈值的比例差异仅为1.2410％.当新型螺旋电极两端的电极触点靠近中间触点时,可以先激活细视神经纤维束,后激活粗纤维束.结论 仿真结果表明新型螺旋电极可以达到传统袖套电极的刺激效果.改变新型螺旋电极的触点位置可以实现选择性激活视神经纤维束.
目的 電刺激中樞神經繫統已用于治療一些神經病、精神病和感覺障礙.儘管在一些應用裏相噹成功,但現有的刺激技術不能精確地控製激活靶嚮神經元.提齣一種形狀自適應的新型螺鏇電極,實現選擇性刺激視神經.方法 應用COMSOL Multiphysics建立視神經和新型螺鏇電極的幾何模型；新型電極由起支撐和絕緣隔離作用的硅橡膠螺鏇支架和嵌入支架內的鉑金觸點組成.引入激活函數來錶徵刺激效果,應用COMSOL倣真分析新型螺鏇電極對視神經纖維選擇性刺激的能力,併攷慮電極觸點位置的變化對選擇性的影響.結果 假定激活函數的歸一化閾值為0.1 V/m2,新型螺鏇電極和傳統袖套電極激活函數大于閾值的比例差異僅為1.2410％.噹新型螺鏇電極兩耑的電極觸點靠近中間觸點時,可以先激活細視神經纖維束,後激活粗纖維束.結論 倣真結果錶明新型螺鏇電極可以達到傳統袖套電極的刺激效果.改變新型螺鏇電極的觸點位置可以實現選擇性激活視神經纖維束.
목적 전자격중추신경계통이용우치료일사신경병、정신병화감각장애.진관재일사응용리상당성공,단현유적자격기술불능정학지공제격활파향신경원.제출일충형상자괄응적신형라선전겁,실현선택성자격시신경.방법 응용COMSOL Multiphysics건립시신경화신형라선전겁적궤하모형；신형전겁유기지탱화절연격리작용적규상효라선지가화감입지가내적박금촉점조성.인입격활함수래표정자격효과,응용COMSOL방진분석신형라선전겁대시신경섬유선택성자격적능력,병고필전겁촉점위치적변화대선택성적영향.결과 가정격활함수적귀일화역치위0.1 V/m2,신형라선전겁화전통수투전겁격활함수대우역치적비례차이부위1.2410％.당신형라선전겁량단적전겁촉점고근중간촉점시,가이선격활세시신경섬유속,후격활조섬유속.결론 방진결과표명신형라선전겁가이체도전통수투전겁적자격효과.개변신형라선전겁적촉점위치가이실현선택성격활시신경섬유속.
Objective Electric stimulation of the central nervous system has been served as a treatment method for variety of neurological,psychiatric and sensory disorders.Despite considerable success in some applications,current stimulation techniques offer little control over which neuronal targets are activated by stimulation.This study aimed to present a new shape self-adaptive helix electrode for selective activation of optic nerve.Methods The geometric model of optic nerve and new helix electrode was elaborated with COMSOL Multiphysics.The new helix electrodes consist of silicone helix frame,which acted as support and insulation,and platinum contacts embedded within the frame.The activating function (AF) was introduced to characterize the stimulation effects,and the selectivity of activating optic nerve fascicle with new helix electrode was simulated by COMSOL Multiphysics,taking into account the variations of electrode contact locations.Results Assuming normalized AF threshold was 0.1 V/m2,the ratio difference of AF over threshold between new helix electrode and traditional electrode was only 1.2410％.With contacts in two ends of helix electrode closer to the middle contact,the small nerve fascicle was first activated and then the large one.Conclusion The results show that the new helix electrodes have the same stimulation effects as that of traditional cuff electrodes.The new helix electrodes can selectively activate optic nerve fascicle with variations of electrode contact locations.
