CAJ | 학술논문

DJ-1是一种广泛表达的多功能蛋白,参与肿瘤的生理病理过程.多数研究显示DJ-1为癌基因,在多种肿瘤中高表达,且在部分肿瘤中可能提示预后不良.DJ-1作为癌基因的机制可能是由于其抗氧化凋亡、抑制PTEN基因信号通路、增强雄激素信号转导等,但也有DJ-1在肿瘤组织中低表达的报道.
DJ-1시일충엄범표체적다공능단백,삼여종류적생리병리과정.다수연구현시DJ-1위암기인,재다충종류중고표체,차재부분종류중가능제시예후불량.DJ-1작위암기인적궤제가능시유우기항양화조망、억제PTEN기인신호통로、증강웅격소신호전도등,단야유DJ-1재종류조직중저표체적보도.
DJ-1, ubiquitously expressed in various human tissues, is a multi-functional protein that plays roles in tumors, Parkinson' s disease, breeding and apoptosis. Over- expression of DJ-1 which is identified as a novel oncogene has been reported in several cancer cells. The underlying mechanisms include the anti-oxi-dative stress reaction, down-regulating phosphatase and tensin homolog deleted on chromosome 10 (PTEN) pathway and up-regulating Androgen pathway. However, there are also some evidences show low-expression of DJ-1 in tumor cells.