CAJ | 학술논문

目的　探讨孕妇血浆血管性假血友病因子(vWF)及内皮素(ET-1)水平变化与妊娠高血压综合征(妊高征)发病的关系。方法　应用酶联免疫吸附试验和放射免疫分析法，分别测定36例妊高征患者(妊高征组)及18例正常妊娠妇女(正常妊娠组)血浆中vWF及ET-1水平，并以19例健康未孕妇女(正常未孕组)为对照。结果　正常妊娠组vWF为（131.6±39.2）%，轻度妊高征患者血浆vWF为（135.9±30.9）%，二者比较，差异无显著性(P>0.05)；正常妊娠组ET-1为（47.1±4.7） pg/L，轻度妊高征患者为（63.7±4.8） pg/L，二者比较，差异有极显著性(P<0.01)。中、重度妊高征患者血浆vWF为（174.4±35.4）%，ET-1为（92.6±19.1） pg/L，与正常妊娠组比较，差异均有极显著性(P<0.01)。妊高征患者血浆vWF与ET-1呈明显正相关。结论　vWF和ET-1可作为判断妊高征病情程度的指标；vWF和ET-1在妊高征发病中起相互协同作用。
목적　탐토잉부혈장혈관성가혈우병인자(vWF)급내피소(ET-1)수평변화여임신고혈압종합정(임고정)발병적관계。방법　응용매련면역흡부시험화방사면역분석법，분별측정36례임고정환자(임고정조)급18례정상임신부녀(정상임신조)혈장중vWF급ET-1수평，병이19례건강미잉부녀(정상미잉조)위대조。결과　정상임신조vWF위（131.6±39.2）%，경도임고정환자혈장vWF위（135.9±30.9）%，이자비교，차이무현저성(P>0.05)；정상임신조ET-1위（47.1±4.7） pg/L，경도임고정환자위（63.7±4.8） pg/L，이자비교，차이유겁현저성(P<0.01)。중、중도임고정환자혈장vWF위（174.4±35.4）%，ET-1위（92.6±19.1） pg/L，여정상임신조비교，차이균유겁현저성(P<0.01)。임고정환자혈장vWF여ET-1정명현정상관。결론　vWF화ET-1가작위판단임고정병정정도적지표；vWF화ET-1재임고정발병중기상호협동작용。
Objective　To study the association of plasma von willebrand factor (vWF) and endothelin-1(ET-1) levels in patients with pregnancy induced hypertension (PIH). Methods　Plasma vWF and ET-1 were studied by ELISA method and immunoradiological method respectively in 36 patients with PIH, 18 normal pregnant women and 19 normal non-pregnant women. Results　Circulation levels of vWF and ET-1 were increased with increasing severity of the PIH. In mild PIH patients, the levels of plasma vWF ［(135.9±30.9)%, （P>0.05)］ weren′t significantly higher than those in healthy pregnant women ［(131.6±39.2)%,（P>0.05)］，but the levels of ET-1 ［(63.7±4.8) pg/L］ were significantly higher than those in healthy pregnant women ［(47.1±4.7) pg/L,（P<0.01)］. There were significant differences between groups of moderate-severe PIH ［vWF (174.4±35.4)%, ET-1 (92.6±19.1) pg/L］. There was a positive correlation between the plasma vWF level and ET-1 level. Conclusion　The results suggested that plasma vWF and ET-1 concentration could be used as indicators for the severity of PIH.