CAJ | 학술논문

目的　观察低浓度克矽平大容量全肺灌洗术治疗煤工尘肺的疗效。方法　42名男性煤工尘肺患者用分层配对方法确定治疗组和对照组。治疗组21名患者接受大容量肺灌洗术治疗。两组随访时进行问诊调查、肺功能和胸部X线摄片检查。结果　肺灌洗治疗能洗出一定量的粉尘，其中快型尘肺平均每例的粉尘洗出量为981.2 mg，明显多于慢型尘肺(386.2 mg),差异有显著性(P<0.05)；治疗组疗前、疗后2年、疗后6 年的FEV1.0值分别为3.35、3.29和2.75 L，对照组为2.95、2.73和2.41 L，均随年龄增加有下降趋势，但两组的差异无显著性(P>0.05)。治疗组治疗后6年胸片的稳定率和进展(进展及明显进展)率分别为42.1%和57.9%，对照组分别为57.9%和42.1%，两组的差异无显著性(P>0.05)。结论　大容量全肺灌洗术能洗出肺内一定量的粉尘，但对肺功能改善和阻止病变进展未见明显疗效。
목적　관찰저농도극석평대용량전폐관세 술치료매공진폐적료효。방법　42명남성매공진폐환자 용분층배대방법학정치료조화대조조。치료조21명환자접수대용량폐관세술 치료。량조수방시진행문진조사、폐공능화흉부X선섭편검사。결과　폐관세치료능세출일정량적분진，기중쾌형진폐평균매례적분진세출량위981.2 mg， 명현다우만형진폐(386.2 mg),차이유현저성(P<0.05)；치료조료전、료후2년、료후6 년적FEV1.0치분별위3.35、3.29화2.75 L，대조조위2.95、2.73화2.41 L，균수년령 증가유하강추세，단량조적차이무현저성(P>0.05)。치료조치료후6년흉편적은정솔화 진전(진전급명현진전)솔분별위42.1%화57.9%，대조조분별위57.9%화42.1%，량조 적차이무현저성(P>0.05)。결론　대용량전폐관세술능세 출폐내일정량적분진，단대폐공능개선화조지병변진전미견명현료효。
Objective　To observe the curative effect of large volume whole lung lavage with low concentration of poly-2-vinyl pyridin e-n-oxide(P204) on the coal workers'pneumoconiosis. Methods　 42 male patients were selected as research subjects.21 patients were selected to accept the treatment and another 21 as controls.A standard questionn aire investigation,lung function and chest X-ray examination were done in both groups of the patients. Results　The mean amount of dust w ashed out from a patient's lung was 981.2 mg in the rapid-type patient group an d 386.2 mg in the slow-type patient group(P<0.05).Before treatment and 2 ye ars,6 years after treatment,the value of FEV1.0,were 3.35 L,3.29 L and 2.75 L respectively in the treatment group,and 2.95 L,2.73 L and 2.41 L respectively in the control group.Lung function decreased in both groups by a ging without statistical difference(P>0.05).6 years after treatment,the rate of stability and aggravation of X-ray examination of chest were 42.1% and 57.9% in treatment group and 57.9% and 42.1% in control group,respectively witho ut statistical difference(P>0.05). Conclusion　The dust could be washed out from the lung by large volume whole lung lavage but there were no evidences of improvement of lu ng function and prevention from aggravation of pathological change 6 years after treatment.