CAJ | 학술논문

恶唑烷酮类化合物是一类新的抗革兰阳性菌化合物.作为恶唑烷酮类化合物的前体药物,苯基取代的恶唑烷酮类可以提高此类化合物的溶解度.本文对苯基恶唑烷酮类的合成关键步骤改进研究,Suzuki偶联反应替代了文献报道的Stille反应,避免了对环境有害的锡化合物的使用.
악서완동류화합물시일류신적항혁란양성균화합물.작위악서완동류화합물적전체약물,분기취대적악서완동류가이제고차류화합물적용해도.본문대분기악서완동류적합성관건보취개진연구,Suzuki우련반응체대료문헌보도적Stille반응,피면료대배경유해적석화합물적사용.
Oxazolidinones are a promising new class of antibacterial agents against numerous Gram-positive organisms.We focused on synthesis of new derivatives of prodruged phenyl oxazolidinone to enhance the solubility of the oxazolidinone compounds.In the key reaction,Suzuki Coupling method was used to replace the literature reported Stille coupling reaction to synthesize prodrug phenyl oxazolidinone without the drawbacks of using tin compounds.