CAJ | 학술논문

目前,妥曲珠利的用药时间和用药途径及其治疗效果存在争议。为了确定妥曲珠利对鸡球虫病的最佳用药时间和途径,本试验以自由饮水和灌服两种途径分别在感染球虫孢子化卵囊后24、48、72 h连续用药2 d,通过抗球虫指数（anticoccidialindex,ACI）、排卵囊减少率和死亡率等指标分析妥曲珠利饮水剂合理用药方案。结果表明,感染后24 h用药妥曲珠利可有效控制鸡柔嫩艾美耳球虫病,48 h后治疗效果不佳;嗉囊灌服的治疗效果优于自由饮水。本试验结果为生产中有效利用妥曲珠利控制鸡球虫病提供了重要依据。
목전,타곡주리적용약시간화용약도경급기치료효과존재쟁의。위료학정타곡주리대계구충병적최가용약시간화도경,본시험이자유음수화관복량충도경분별재감염구충포자화란낭후24、48、72 h련속용약2 d,통과항구충지수（anticoccidialindex,ACI）、배란낭감소솔화사망솔등지표분석타곡주리음수제합리용약방안。결과표명,감염후24 h용약타곡주리가유효공제계유눈애미이구충병,48 h후치료효과불가;소낭관복적치료효과우우자유음수。본시험결과위생산중유효이용타곡주리공제계구충병제공료중요의거。
There has been controversy in the optimal time, route and efficacy for Toltrazuril, a novel anticoccidial drug against Avian coecidiosis. In the present study, Toltrazuril was administered into 14 days old chickens for two days via drinking water or crop drench at 24, 48h and 72h post infection with sporulated oocysts ofEimeria tenella. The anticoccidial index （ACI）, reducing oocyst output and mortality were observed. The results showed Toltrazuril was effective in control of E. tenella infection at 24 h after infection but became useless at 48h and 72 h. Besides, crop drench was more effective route than free drinking. These findings provided important reference for the effective usage of Toltrazuril to control coccidiosis in chickens.