CAJ | 학술논문

[目的]探讨雄激素受体、p16蛋白在乳腺癌中的表达情况及其临床价值。[方法]应用SP免疫组织化学方法对61例乳腺癌组织中雄激素受体及cDKNI抑癌基因p16蛋白表达进行研究。[结果]雄激素受体阳性表达与乳腺癌的淋巴结转移呈负相关(P<0.05），与5年生存期呈正相关(P＜0.005)，与p16蛋白表达呈正相关(P<0.005)。[结论]雄激素受体与p16蛋白表达可结合起来作为乳腺癌的一个生物学指标及预后的判断指标，为内分泌治疗提供理论依据。
[목적]탐토웅격소수체、p16단백재유선암중적표체정황급기림상개치。[방법]응용SP면역조직화학방법대61례유선암조직중웅격소수체급cDKNI억암기인p16단백표체진행연구。[결과]웅격소수체양성표체여유선암적림파결전이정부상관(P<0.05），여5년생존기정정상관(P＜0.005)，여p16단백표체정정상관(P<0.005)。[결론]웅격소수체여p16단백표체가결합기래작위유선암적일개생물학지표급예후적판단지표，위내분비치료제공이론의거。
[Purpose] To explore the expression of androgen receptor and p16 protein in breast carcinoma, and its clinical significance.[Methods] The expression of androgen receptor and p16 protein was examined by means of SP immunohistochemical technique in 61 cases with breast cancer proved by pathology. [Results]The expression of androgen receptor (AR) revealed negative correlation with lymph node metastasis (P<0.05), and positive correlation with 5-year survival (P<0.005) in patients with breast cancer. The expression of AR was positive correlation with p16 protein in breast cancer (P<0.005).[Conclusion] Combination of AR and p16 protein should determined as a biological factor and prognostic factor for breast cancer,which can provide the theoretial warranty for hormonal therapy.