CAJ | 학술논문

目的：研究高血压动脉硬化对脑血流自动调节类型的影响，提出脑血流自动调节下限测定的新方法。方法：经颅多普勒超声测定血流速度，同步记录血压，改变血压，绘制脑血流自动调节曲线，并进行分类和确定自动调节的上、下限。同时，自动调节下限也按照临界关闭压（CCP）的理论进行测定。结果：脑血流自动调节类型中，经典型和非经典型降血压中正常鼠为25%和75%，肾血管性高血压大鼠（RHR）为40.55%和54.45%；升血压中正常鼠为76.47%和23.53%，RHR全为经典型。CCP法检测到的自动调节下限正常鼠和RHR分别为(70.88±24.05) mmHg和(107.73±38.82) mmHg，与自动调节曲线测定的结果高度相关（r分别为0.79455和0.81643，P均＜0.01），数值相近。结论：高血压动脉硬化除使脑血流自动调节范围上移外，其类型也发生改变；自动调节下限的测定，用TCD按照CCP理论进行，结果可靠，可代替常规方法。
목적：연구고혈압동맥경화대뇌혈류자동조절류형적영향，제출뇌혈류자동조절하한측정적신방법。방법：경로다보륵초성측정혈류속도，동보기록혈압，개변혈압，회제뇌혈류자동조절곡선，병진행분류화학정자동조절적상、하한。동시，자동조절하한야안조림계관폐압（CCP）적이론진행측정。결과：뇌혈류자동조절류형중，경전형화비경전형강혈압중정상서위25%화75%，신혈관성고혈압대서（RHR）위40.55%화54.45%；승혈압중정상서위76.47%화23.53%，RHR전위경전형。CCP법검측도적자동조절하한정상서화RHR분별위(70.88±24.05) mmHg화(107.73±38.82) mmHg，여자동조절곡선측정적결과고도상관（r분별위0.79455화0.81643，P균＜0.01），수치상근。결론：고혈압동맥경화제사뇌혈류자동조절범위상이외，기류형야발생개변；자동조절하한적측정，용TCD안조CCP이론진행，결과가고，가대체상규방법。
AIM:To study the effect of hypertensive arteriosclerosis on cerebral blood flow autoregulation (CBFA), and to introduce a new method to measure the lower limit. METHODS:The blood velocities and blood pressure was recorded simultaneously and the curves of CBFA were analyzed and classified into classical and non-classical pattern. The lower limit were determined by clinical closing pressure (CCP) and the curve CBFA. RESULTS:When the blood pressure was decreasing, the classical and non-classical pattern of the cerebral blood flow autoregulation were 25% and 75% respectively in normal SD rats, while they were 40.55% and 54.45% respectively in renovascular hypertensive rats (RHR). However, when the blood pressure was elevating, the classical and non-classical pattern were 76.47% and 23.53% respectively in SD rats, while they were all classical in RHR. Furthermore, in SD and RHR ras, the lower limits measured by CCP were well in accordance with that measured by CBFA. CONCLUSION:Hypertensive arteriosclerosis could influence the limits and the patterns of cerebral blood flow autoregulation. The lower limit of CBFA can be measured and analyzed by CCP.