中国肿瘤临床与康复
中國腫瘤臨床與康複
중국종류림상여강복
CHINESE JOURNAL OF CLINICAL ONCOLOGY AND REHABILITATION
2001年
2期
37-38,36
,共3页
李西启%宫兆松%李晓东%刘淑皎%王剑波%姜元庆%徐廷香%王涛%刘彦仿
李西啟%宮兆鬆%李曉東%劉淑皎%王劍波%薑元慶%徐廷香%王濤%劉彥倣
리서계%궁조송%리효동%류숙교%왕검파%강원경%서정향%왕도%류언방
阴茎肿瘤%人乳头瘤病毒%a-转化生长因子%表皮生长因子受体
陰莖腫瘤%人乳頭瘤病毒%a-轉化生長因子%錶皮生長因子受體
음경종류%인유두류병독%a-전화생장인자%표피생장인자수체
目的为了探讨TGF-a，EGF-R和HPV 与阴茎癌发生的关系。方法用免疫组化和原位PCR技术对78例阴茎癌组织进行检测。结果 HPVDNA阳性率为69.2%(54/78)，其中HPV16阳性49例，HP V18阳性8例，HPV16和HPV18均阳性3例，TGF-a阳性率为74.4%(58/78)，58例TGF-a阳性中有4 9例HPVDNA阳性。EGF-R阳性率为38.5%(30/78)，其中93.7%TGF-a阳性(28/30)。结论阴茎癌的发生与HPV感染、TGF-a、EGF-R过表达有密切关系。
目的為瞭探討TGF-a，EGF-R和HPV 與陰莖癌髮生的關繫。方法用免疫組化和原位PCR技術對78例陰莖癌組織進行檢測。結果 HPVDNA暘性率為69.2%(54/78)，其中HPV16暘性49例，HP V18暘性8例，HPV16和HPV18均暘性3例，TGF-a暘性率為74.4%(58/78)，58例TGF-a暘性中有4 9例HPVDNA暘性。EGF-R暘性率為38.5%(30/78)，其中93.7%TGF-a暘性(28/30)。結論陰莖癌的髮生與HPV感染、TGF-a、EGF-R過錶達有密切關繫。
목적위료탐토TGF-a，EGF-R화HPV 여음경암발생적관계。방법용면역조화화원위PCR기술대78례음경암조직진행검측。결과 HPVDNA양성솔위69.2%(54/78)，기중HPV16양성49례，HP V18양성8례，HPV16화HPV18균양성3례，TGF-a양성솔위74.4%(58/78)，58례TGF-a양성중유4 9례HPVDNA양성。EGF-R양성솔위38.5%(30/78)，기중93.7%TGF-a양성(28/30)。결론음경암적발생여HPV감염、TGF-a、EGF-R과표체유밀절관계。
Objective To study the relationship between the e x pression of TGF-a，EGF-R and HPV infection in penile carcinoma.Methods Immunohistochemical and in situ PCR were used to detect the expression of TGF-a，EGF-R and HPV in 78 cases of penile carcinoma.Results HPV DNA was observed to be possitive in 54 cases (69.2%),of which 49 were H PV 16 possitive and 8 were HPV 18 positive,3 cases were both HPV 16 and HPV18 po sitive. TGF-a was detected in 58 casses (74.4%),of which 49(84.5%) were HPV po sitvie.EGF-R was detected in 30 cases (38.5%),of which 28(93.3%)were TGF-a positive.Conclusions There is a close relationship between HPV infection and expression of TGF-a and EGF-R in the development of penile carcinoma.
