中国矫形外科杂志
中國矯形外科雜誌
중국교형외과잡지
THE ORTHOPEDIC JOURNAL OF CHINA
2001年
2期
156-157
,共2页
陈建常%史振满%王乐农%卢开柏
陳建常%史振滿%王樂農%盧開柏
진건상%사진만%왕악농%로개백
肢体%缺血再灌注损伤%关节软骨%滑膜%组织学
肢體%缺血再灌註損傷%關節軟骨%滑膜%組織學
지체%결혈재관주손상%관절연골%활막%조직학
目的：通过动物实验观察肢体缺血再灌注后关节软骨和滑膜病理变化。方法：35只新西兰大白兔随机分成缺血2、5h和正常对照3个组。分别于缺血、再灌注后1d和1、4、8、12、16周取关节软骨和滑膜行大体和光镜观察，测量8和16周软骨各层厚度，并进行定量分析。结果：肢体缺血再灌注1周内关节软骨及滑膜表现为缺血再灌注损伤，4周后渐出现退行性关节炎的早期改变，缺血5h组重于缺血2h组。结论：缺血再灌注肢体关节软骨、滑膜有缺血再灌注损伤，可逐渐演变成骨性关节炎。
目的：通過動物實驗觀察肢體缺血再灌註後關節軟骨和滑膜病理變化。方法：35隻新西蘭大白兔隨機分成缺血2、5h和正常對照3箇組。分彆于缺血、再灌註後1d和1、4、8、12、16週取關節軟骨和滑膜行大體和光鏡觀察，測量8和16週軟骨各層厚度，併進行定量分析。結果：肢體缺血再灌註1週內關節軟骨及滑膜錶現為缺血再灌註損傷，4週後漸齣現退行性關節炎的早期改變，缺血5h組重于缺血2h組。結論：缺血再灌註肢體關節軟骨、滑膜有缺血再灌註損傷，可逐漸縯變成骨性關節炎。
목적：통과동물실험관찰지체결혈재관주후관절연골화활막병리변화。방법：35지신서란대백토수궤분성결혈2、5h화정상대조3개조。분별우결혈、재관주후1d화1、4、8、12、16주취관절연골화활막행대체화광경관찰，측량8화16주연골각층후도，병진행정량분석。결과：지체결혈재관주1주내관절연골급활막표현위결혈재관주손상，4주후점출현퇴행성관절염적조기개변，결혈5h조중우결혈2h조。결론：결혈재관주지체관절연골、활막유결혈재관주손상，가축점연변성골성관절염。
Objective: An experimental study to observe histological change of articular cartilage and synovial injury after ischemia in the hind limbs.Methods:35 rabbits were divided into normal control group,ischemia 2 hours group and ischemia 5 hours group.Gross observation and histological examination of the specimens were performed at 0,48 hours and 1,4,8,12,16 weeks after reperfusion.Calcified and noncalcified cartilage were measured and analysed quantitatively at 8,16 weeks after reperfusion.Results:The ischemia and reperfusion injury and degenerative change of articular cartilage and synovialis were found in experimental groups.the change was more obvious in ischemia 5 hours group compared with in ischemia 2 hours group.Conclusion:The reperfusion injury after ischemia in hind limbs may relate with degenerative osteoarthritis.
