CAJ | 학술논문

目的：了解H受体阻滞剂在手术并发急性肺损伤（ALI）中的作用。方法：腹部手术中采用油酸静脉注射造成急性肺损伤，观察盐酸异丙嗪（H１受体阻滞剂）和西米替丁（H2受体阻滞剂）对损伤肺嗜中性粒细胞聚集及对氧自由基水平的影响。结果：两者均能有效地抑制嗜中性粒细胞在肺内的聚集，对氧自由基的产生有一定抑制作用，西米替丁的作用更为明显。结论：H受体阻滞剂特别是H２受体阻滞剂可作为术中及术后预防和治疗急性肺损伤的药物。
목적：료해H수체조체제재수술병발급성폐손상（ALI）중적작용。방법：복부수술중채용유산정맥주사조성급성폐손상，관찰염산이병진（H１수체조체제）화서미체정（H2수체조체제）대손상폐기중성립세포취집급대양자유기수평적영향。결과：량자균능유효지억제기중성립세포재폐내적취집，대양자유기적산생유일정억제작용，서미체정적작용경위명현。결론：H수체조체제특별시H２수체조체제가작위술중급술후예방화치료급성폐손상적약물。
Objective To study the effect of H-recepter blocking agent in operation and ALI.Method In abdomen operation with ALI caused by intravenous injection of oleic acid，the influence of promethazine hydrochloride and cimetidini on the aggregation of neutrophilic granulocytes of injured lungs and oxygen freeradical level were observed.Results Both of them can effectively inhibit the aggregation of neutrophilic granulocytes and had some inhibiting effect on free-radical of oxygen，especially cimetidini.Conclusion H-recepter blocking agent，especially H２ recepter blocking agent can be used during or after operation to prevent and treat ALI.