CAJ | 학술논문

目的探讨卵巢癌腹水的综合治疗方法。方法 72例均经腹腔穿刺排净腹水。71例细胞学查到癌细胞的腹腔注入化疗药物。分3组：顺铂组(DDP)18例，80～100mg/次;卡铂组(CBP)48例,CBP400～500mg/次;DDP+CBP组5例,DDP或CBP交换应用。配合静脉联合化疗1～2个疗程后手术切除肿瘤。术后再配合腹腔及静脉化疗。一般腺癌、性索间质肿瘤选用VCP、CAP或EAP方案，生殖细胞肿瘤选用VCA或EBP方案。一年内给予规范性化疗8～12个疗程。结果腹腔化疗消除腹水CBP组较DDP组满意(P＜0.05)。总的腹水完全控制率为80.3%,肿瘤完全切除率为59.2%。结论卵巢癌合并腹水需采用包括化疗及手术在内的综合治疗。
목적 탐토란소암복수적종합치료방법。방법 72례균경복강천자배정복수。71례세포학사도암세포적복강주입화료약물。분3조：순박조(DDP)18례，80～100mg/차;잡박조(CBP)48례,CBP400～500mg/차;DDP+CBP조5례,DDP혹CBP교환응용。배합정맥연합화료1～2개료정후수술절제종류。술후재배합복강급정맥화료。일반선암、성색간질종류선용VCP、CAP혹EAP방안，생식세포종류선용VCA혹EBP방안。일년내급여규범성화료8～12개료정。결과 복강화료소제복수CBP조교DDP조만의(P＜0.05)。총적복수완전공제솔위80.3%,종류완전절제솔위59.2%。결론 란소암합병복수수채용포괄화료급수술재내적종합치료。
Objective To investigate combined therapy method of ovariancarcinoma complicated with ascites.Methods 72 patients were performed abdominocentesis and aspirated Ascites completely.Intraperitoneal(IP)chemotherapy was given for positive ascitic cytology of 71 patients.They were divided into three groups:18 case were treated by IP of DDP(80～100mg/body);48 by IP of carboplatin (CBP,400～500mg/body);and 5 by IP of DDP and CBP alternately.IP and intravenous(IV) chemotherapy 1～2 therapeutic courses followed by operation.After operation, all patients received chemotherapy by IP or IV. VCP, CAP or EAP schemes were used in adenocarcinoma or sex cord stromal tumors .VAC or EBP scheme was selected for germ cell tumors. The chemotherapy was performed for 8～12 therapeutic courses in one year.Results Ascites elimination were satisfactory in CBP group than DDP(P＜0.05). The overall ascites complete remission rate was 80.3%.Tumors complete resection rate was 59.2%.Conclusion The treatment of ovarian carcinoma complicated with Ascites must be used combined therapy while were IP, IV and operation.