CAJ | 학술논문

目的：了解慢性阻塞性肺病下呼吸道院内感染的病原菌分布及药敏情况。方法：对265例慢性阻塞性肺病(COPD)下呼吸道院内感染患者进行痰细菌培养分离，并对分离出的细菌进行药物敏感试验(药敏)。结果：184例培养阳性，阳性率69.4%；共检出细菌224株，以革兰阴性(G-)杆菌为主(76.3%)；2种以上细菌混合感染40例(21.7%)；金黄色葡萄球菌(金葡菌)、不动杆菌、铜绿假单胞菌及阴沟杆菌为主要致病菌。药敏发现头孢他定、妥布霉素、头孢曲松、氧氟沙星、万古霉素为敏感抗生素。结论：COPD下呼吸道多种细菌混合感染常见，且耐药严重。临床上应加强药敏测定，合理应用抗生素，联合用药，减少细菌耐药性的产生。
목적：료해만성조새성폐병하호흡도원내감염적병원균분포급약민정황。방법：대265례만성조새성폐병(COPD)하호흡도원내감염환자진행담세균배양분리，병대분리출적세균진행약물민감시험(약민)。결과：184례배양양성，양성솔69.4%；공검출세균224주，이혁란음성(G-)간균위주(76.3%)；2충이상세균혼합감염40례(21.7%)；금황색포도구균(금포균)、불동간균、동록가단포균급음구간균위주요치병균。약민발현두포타정、타포매소、두포곡송、양불사성、만고매소위민감항생소。결론：COPD하호흡도다충세균혼합감염상견，차내약엄중。림상상응가강약민측정，합리응용항생소，연합용약，감소세균내약성적산생。
Objective: To analyse the pathogen of chronic obstructive pulmonary diseases(COPD) with low respiratory tract infection.Methods:Becterial cultures of sputum from 265 cases of COPD with low respiratory tract infection were performed and drug sensitivity was tested among positive cases. Results:184 cases were positive (69.4%) and 224 strains becteria were obtained. 40 patients(21.7%) were infected by two or more kinds of becteria.The main pathogens were staphylococcus aureus, acinetorbacter,pseudomonas aeruginosa and enterobacter cloacae.Drug sensitivity test showed that ceftazidime,vancomycin,tobramycin,ceftrioxome,ofloxacin were effective drugs. Conclusion:Low respiratory tract infection by becteria in patients with COPD was common and drug resistence rate of microbe was very high.So drug sensitivity test should be done more often and antibiotics must be selected according to the test.