CAJ | 학술논문

目的探讨粘附分子E-Cadherin和与肺癌淋巴转移的关系。方法采用免疫组化SP法检测了63例肺癌组织及其中41例淋巴转移灶中E-Cadherin和的表达。结果淋巴转移灶中阳性表达率为85．37％，显著高于原发灶(63．49％，P＜0．05)；E-Cadherin均与肺癌淋巴转移密切相关(P值分别小于0．05和0．001)；诊断肺癌淋巴转移的敏感度和特异度E-Cadherin异常表达为63．41％和63．64％，阳性表达为85．37％和77．27％，平行试验敏感度为87．80％，特异度为59．09％，系列试验敏感度为60．98％，特异度为81．18％。结论 E-Cadherin异常表达和阳性表达可能均在肺癌淋巴转移中起重要的促进作用，可作为诊断肺癌淋巴转移的辅助指标。
목적탐토점부분자E-Cadherin화여폐암림파전이적관계。방법채용면역조화SP법검측료63례폐암조직급기중41례림파전이조중E-Cadherin화적표체。결과림파전이조중양성표체솔위85．37％，현저고우원발조(63．49％，P＜0．05)；E-Cadherin균여폐암림파전이밀절상관(P치분별소우0．05화0．001)；진단폐암림파전이적민감도화특이도E-Cadherin이상표체위63．41％화63．64％，양성표체위85．37％화77．27％，평행시험민감도위87．80％，특이도위59．09％，계렬시험민감도위60．98％，특이도위81．18％。결론 E-Cadherin이상표체화양성표체가능균재폐암림파전이중기중요적촉진작용，가작위진단폐암림파전이적보조지표。
Objective To study the relationship between expression of cell adhesion molecules E-Cadherin and and lymph node metastasis in lung carcinoma. Methods Immunohistochemical SP method had been used to detect expressions of E-Cadherin and in 63 primary lung cancer tissues and 41 metastatic lymph nodes. Results The positive rate of expression in metastatic lymph nodes was 85.37 % (35/41), which was significantly higher than that in primary spots( P < 0.05). Either E-Cadherin or was distinctly correlated with lymph node involvements in lung cancer(P<0.05 and <0. 001 respectively). The sensitivity and the specificity of E-Cadherin abnormal expression positive expression, parallel and cascade test in diagnosing lymph node metastasis of lung cancer were 63.41% and 63.64%, 85.37% and 77.27%, 87.80% and 59.09%, 60.98% and 81.18%, respectively. Conclusion These results indicate that the E-Cadherin and CD44v6 play an important promoting role in lymph node metastasis in lung cancer.