中国临床康复
中國臨床康複
중국림상강복
CHINESE JOURNAL OF CLINICAL REHABILITATION
2002年
6期
906-907
,共2页
陈礼明%朴永旭%毛伯镛%高立达%卢敏%曾凡俊%王方
陳禮明%樸永旭%毛伯鏞%高立達%盧敏%曾凡俊%王方
진례명%박영욱%모백용%고립체%로민%증범준%왕방
spinal cord injury%microgene%enzyme histochemistry%immunohistochemistry
spinal cord injury%microgene%enzyme histochemistry%immunohistochemistry
spinal cord injury%microgene%enzyme histochemistry%immunohistochemistry
Objective To provide morphological evidence for therapeutic effects of microgene pSVPoMcat implanted to modify schwann cells(SC) on the experimental spinal cord injury(SCI).Methods Experimental animals were divided into three groups: the group of microgene pSVPoMcat implanted to genetically SC(group A),SC implanted group(group B) and the control group(group C),each groups having 10 animals.Acetylcholinesterase(AchE) and acid phosphatase(ACP)activity of anterior horn cells in the A,B,C groups were measured respectively with the quantitative enzyme histochemistry ;The number of axon in the spinal white matter was surveyed in the three groups by means of the quantitative immunohitochemistry. Results (1)AchE activity of anterior horn cells in the A,B,C groups were A< B< C at various time,and ACP activity were A >B >C;(2)The number of axon in a certain area of spinal white matter in the A,B,C were A >B >C.Conclusion The therapeutic effects of microgene pSVPoMcat implanted to modify SC on the experimental SCI have the reliable morphological evidence.