时珍国医国药
時珍國醫國藥
시진국의국약
LISHIZHEN MEDICINE AND MATERIA MEDICA RESEARCH
2009年
11期
2810-2812
,共3页
接骨七厘散软胶囊%湿法超微粉碎%PEG400%生物利用度
接骨七釐散軟膠囊%濕法超微粉碎%PEG400%生物利用度
접골칠전산연효낭%습법초미분쇄%PEG400%생물이용도
Jie Gu Qi Li San soft capsule%Frequent vibrating pulverization by wet processing%PEG -400%Bioavailability
目的 湿法超微粉碎技术对接骨七厘散工艺改进和剂型改革,考察接骨七厘散软胶囊内容物的最佳湿法超微粉碎工艺参数.方法 以物料粒度(D_(50)和D_(90))、物料稳定性等作考察指标,采用单因素考察法分别对分散介质、介质用量等工艺参数进行筛选.结果 软胶囊内容物的最佳湿法超微粉碎工艺为:加1.5倍量预保温PEG400,40 ℃以下超微粉碎35 min,出料,即得.结论 湿法超微粉碎工艺简便,效率高,不仅使物料粒度变细提高了药物生物利用度,节省药源,同时使物料均质化程度更高,便于制剂,具有广阔的应用前景.
目的 濕法超微粉碎技術對接骨七釐散工藝改進和劑型改革,攷察接骨七釐散軟膠囊內容物的最佳濕法超微粉碎工藝參數.方法 以物料粒度(D_(50)和D_(90))、物料穩定性等作攷察指標,採用單因素攷察法分彆對分散介質、介質用量等工藝參數進行篩選.結果 軟膠囊內容物的最佳濕法超微粉碎工藝為:加1.5倍量預保溫PEG400,40 ℃以下超微粉碎35 min,齣料,即得.結論 濕法超微粉碎工藝簡便,效率高,不僅使物料粒度變細提高瞭藥物生物利用度,節省藥源,同時使物料均質化程度更高,便于製劑,具有廣闊的應用前景.
목적 습법초미분쇄기술대접골칠전산공예개진화제형개혁,고찰접골칠전산연효낭내용물적최가습법초미분쇄공예삼수.방법 이물료립도(D_(50)화D_(90))、물료은정성등작고찰지표,채용단인소고찰법분별대분산개질、개질용량등공예삼수진행사선.결과 연효낭내용물적최가습법초미분쇄공예위:가1.5배량예보온PEG400,40 ℃이하초미분쇄35 min,출료,즉득.결론 습법초미분쇄공예간편,효솔고,불부사물료립도변세제고료약물생물이용도,절성약원,동시사물료균질화정도경고,편우제제,구유엄활적응용전경.
Objective To explore the optimal ultra - fine pulverization procedure for the content of Jie Gu Qi Li San soft capsule by wet processing. Methods Using the particle size (D_(50) and D_(90)) , station and so on of the contents from Jie Gu Qi Li San soft capsule as main indicators, the pulverization progress was studied by single factor method. In this way, the effects of such conditions as pulverizing time, mediator consumption, pulverizing temperature and so on extracting rate were investigated. Results The optimal pulverization procedure for the content of Jie Gu Qi Li San soft capsule was 1.5 times of PEG400, vibrating frequently 35 minutes under 40℃. Conclusion The optimum pulverizing procedure is convenient, and applicable to the preparation of Jie Gu Qi Li San Soft Capsule. It should have a good future.
