陕西师范大学学报（自然科学版）
陝西師範大學學報（自然科學版）
협서사범대학학보（자연과학판）
JOURNAL OF SHAANXI NORMAL UNIVERSITY(NATURAL SCIENCE EDITION)
2010年
1期
54-56
,共3页
盐酸二甲双胍%化学发光%流动注射%luminol%Cu(Ⅱ)
鹽痠二甲雙胍%化學髮光%流動註射%luminol%Cu(Ⅱ)
염산이갑쌍고%화학발광%류동주사%luminol%Cu(Ⅱ)
metformin hydrochloride%chemiluminescence%flow injection%luminol%Cu(Ⅱ)
在Cu(Ⅱ)存在下,研究了luminol-Cu(Ⅱ)-盐酸二甲双胍化学发光体系,建立了测定盐酸二甲双胍的流动注射化学发光新方法.结果表明,在优化的实验条件下,化学发光强度与盐酸二甲双胍浓度在1.0×10~(-9)～1.0×10~(-7) g/mL范围内呈线性关系.该方法测定盐酸二甲双胍的检出限为5×10~(-10)g/mL,相对标准偏差为1.1%(1.0×10~(-8)g/mL盐酸二甲双胍溶液,n=11).该方法已用于片剂中盐酸二甲双胍含量的测定.
在Cu(Ⅱ)存在下,研究瞭luminol-Cu(Ⅱ)-鹽痠二甲雙胍化學髮光體繫,建立瞭測定鹽痠二甲雙胍的流動註射化學髮光新方法.結果錶明,在優化的實驗條件下,化學髮光彊度與鹽痠二甲雙胍濃度在1.0×10~(-9)～1.0×10~(-7) g/mL範圍內呈線性關繫.該方法測定鹽痠二甲雙胍的檢齣限為5×10~(-10)g/mL,相對標準偏差為1.1%(1.0×10~(-8)g/mL鹽痠二甲雙胍溶液,n=11).該方法已用于片劑中鹽痠二甲雙胍含量的測定.
재Cu(Ⅱ)존재하,연구료luminol-Cu(Ⅱ)-염산이갑쌍고화학발광체계,건립료측정염산이갑쌍고적류동주사화학발광신방법.결과표명,재우화적실험조건하,화학발광강도여염산이갑쌍고농도재1.0×10~(-9)～1.0×10~(-7) g/mL범위내정선성관계.해방법측정염산이갑쌍고적검출한위5×10~(-10)g/mL,상대표준편차위1.1%(1.0×10~(-8)g/mL염산이갑쌍고용액,n=11).해방법이용우편제중염산이갑쌍고함량적측정.
A new chemiluminescence system, luminol-Cu(Ⅱ)-metformin hydrochloride system, was investigated for the determination of metformin hydrochloride. The experimental conditions were carefully optimized. Under the optimum conditions, the concentration of metformin hydrochloride related to the chemiluminescence intensity was linear in the range of 1.0×10~(-9) 1.0×10~(-7)g/mL. The detection limit of the method was 5 ×10~(-10) g/mL. The relative standard deviation was 1. 1% for the 11 replicated determinations of 1. 0×10~(-8)g/mL metformin hydrochloride. The proposed method was applied to the determination of metformin hydrochloride in tablets.
