CAJ | 학술논문

目的观察热灌注化疗对兔VX2肝癌模型疗效及安全性.方法新西兰大白兔20只,制备兔肝VX2模型,随机分为对照组(A)和实验组(B),分别A组给于常温(22～250C)5%匍萄糖100 ml+5.Fu(20 mg/kg),B组给于60℃5%葡萄精100 ml+5-Fu(20 mg/kg),用B超观察处理前后肿瘤大小,抽血查ALT变化.结果 A组肿瘤体积由(1 627±473)mm~3缩小为(1 334±641)mm~3,B组肿瘤体积由(1 682±397)mm~3缩小为(1 130±559)mm~3,两组差别有统计学意义(P＜0.05);ALT A组由(755±203)u/L增加为(834±262)u/L,B组由(78l±197)u/L增加为(865±237)u/L,组间差异无统计学意义.结论介入性热灌注化疗比常温灌注化疗对兔VX2肝癌模型有更高的抑制作用.
목적 관찰열관주화료대토VX2간암모형료효급안전성.방법 신서란대백토20지,제비토간VX2모형,수궤분위대조조(A)화실험조(B),분별A조급우상온(22～250C)5%포도당100 ml+5.Fu(20 mg/kg),B조급우60℃5%포도정100 ml+5-Fu(20 mg/kg),용B초관찰처리전후종류대소,추혈사ALT변화.결과 A조종류체적유(1 627±473)mm~3축소위(1 334±641)mm~3,B조종류체적유(1 682±397)mm~3축소위(1 130±559)mm~3,량조차별유통계학의의(P＜0.05);ALT A조유(755±203)u/L증가위(834±262)u/L,B조유(78l±197)u/L증가위(865±237)u/L,조간차이무통계학의의.결론 개입성열관주화료비상온관주화료대토VX2간암모형유경고적억제작용.
Objective To evaluate the effectiveness and safety of interventional thermochemotherapy for VX2 transplanted hepatic tumor model in experimental rabbits.Methods The hepatic tumor model was established in 20 New Zealand rabbits by implanting VX2 tumor cells into the right hepatic lobes of the rabbits.The rabbits were randomly and equally divided into two groups with 10 rabbits in each group:group A (study group)and group B(control group).Via the femoral access,the catheter was placed into the tumorfeeding artery,which was confirmed by DSA.The rabbits in group A received an infusion of 100 ml 5% glucose plus 5-Fu(20 mg/kg)at 60℃ temperature,while the rabbits in group B received an infusion of 100 ml 5% glucose plus 5-Fu(20 mg/kg)at normal room temperature(22-25℃).Before and after the procedure,the tumor size was measured by means of B ultrasonography and the serum ALT was estimated to assess the liver function.The results were statistically compared between two groups.Results After the treatment,the tumor size in group A(study group)became much smaller than that in group B(control group),with P＜0.05.And no significant difference in the serum ALT level existed between group A and group B.Conclusion The interventional thermochemotherapy is superior to interventional chemotherapy in inhibiting VX2 transplanted hepatic tumor in experimental rabbits.