CAJ | 학술논문

目的观察安体维康对D-半乳糖胺(D-GlaN)所致急性肝损伤和慢性乙型肝炎的保肝降酶作用.方法给小鼠腹腔注射D-半乳糖胺800 mg/kg造模,48 h后血清转氨酶ALT和AST均明显升高;病理观察呈急性肝细胞损伤表现.临床观察采用配对分组法,分为慢性乙型肝炎治疗组60例,口服安体维康胶囊和水飞蓟素片;对照组57例,口服水飞蓟素片.两组均静滴甘利欣.结果 ①联苯双脂和安体维康1.6 g、3.2g、6.4g/kg 3个剂量组均能明显对抗血清AST水平的增高(P值分别＜0.001、＜0.01、＜0.01、＜0.001);病理观察,安体维康3个剂量组均能明显减轻D-半乳糖胺所致小鼠肝组织病变程度(P＜0.01、＜0.05、＜0.01、＜0.01).②慢性肝炎患者治疗3个月后,治疗组与对照组的ALT复常率分别是96.67%(58160)、92.98%(53/57),无显著性差异(P＞0.02);AST复常率分别为95%(57/60)、78.9%(45/57),有显著性差异(P＜0.01);血清胆红素的复常率未见显著性差异.结论安体维康对D-半乳糖胺急性肝损伤小鼠和慢性乙型肝炎患者均具有明显的保护作用.
목적 관찰안체유강대D-반유당알(D-GlaN)소치급성간손상화만성을형간염적보간강매작용.방법 급소서복강주사D-반유당알800 mg/kg조모,48 h후혈청전안매ALT화AST균명현승고;병리관찰정급성간세포손상표현.림상관찰채용배대분조법,분위만성을형간염치료조60례,구복안체유강효낭화수비계소편;대조조57례,구복수비계소편.량조균정적감리흔.결과 ①련분쌍지화안체유강1.6 g、3.2g、6.4g/kg 3개제량조균능명현대항혈청AST수평적증고(P치분별＜0.001、＜0.01、＜0.01、＜0.001);병리관찰,안체유강3개제량조균능명현감경D-반유당알소치소서간조직병변정도(P＜0.01、＜0.05、＜0.01、＜0.01).②만성간염환자치료3개월후,치료조여대조조적ALT복상솔분별시96.67%(58160)、92.98%(53/57),무현저성차이(P＞0.02);AST복상솔분별위95%(57/60)、78.9%(45/57),유현저성차이(P＜0.01);혈청담홍소적복상솔미견현저성차이.결론 안체유강대D-반유당알급성간손상소서화만성을형간염환자균구유명현적보호작용.
Objective To observe the effect of Antivirus Compound Capsule in protecting liver and reducing enzyme level in chronic type B hepatitis and acute hepatic injury caused by D-GlaN.Methods Mice model was established by intraperitoneal injecting of D-GlaN 800mg/Kg.The level of ALT and AST was obviously increased after 48hours.Pathological test proved to be acute liver cell damage.Clinically 117 cases of chronic hepatitis B was recruited into a control group(57 cases)and a treatment group(60 cases).The treatment group was treated with Antivims Compound Capsule and Silymarin tablet,and the control group was treated with Silymarin tablet.Besides,both groups were infused with diammonium Compound Capsule Can obviously reduce level of AST(P＜0.001、＜0.01、＜0.01、＜0.001);Three dosage levels of Antivirus Compound Capsule can obviously reduce the degree hepatic pathological changes caused by D-GlaN induced(P＜0.01、＜for the treatment group andtlle control group) between the two groups with P＞0.02.while there was obvious difference of negative conversion rate of AST.[92.98%(53/57)and 78.9%(45/57)for the treaunent group and the consul group]between the two groups with P＜0.01.Conclusion Antivirus Compound Capsule is effective in protecting liver and reducing enzyme level of patients with chronic hepatitis B and acute hepatic injury caused bv D-GlaN.