CAJ | 학술논문

目的：研究老年多梗塞性痴呆(MID)的性激素。方法：采取放射免疫法测定老年多梗塞痴呆46例，老年非痴呆脑梗塞(CI)62例，正常老年健康对照组38例。结果：男性MID组和CI组分别与对照组的比较， T值下降， E2/T增高，均有显著性差异(P<0.05)， MID组E2高于对照组，有显著性差异(P<0.05)， CI组与对照组E2比较无显著差异(P>0.05)。女性MID组和CI组分别与对照组比较， T值下降，有显著性差异(P<0.05)， E2更明显下降，有高度显著差异(P<0.001)， PRL和PRO及E2/T值无显著性差异。男女性老年多梗塞性痴呆与非痴呆性脑梗塞组分别比较T、 PRO、 E2/T、均无显著性差异(P>0.05)。结论：老年多梗塞性痴呆与非痴呆性脑梗塞都存在着性激素失衡，其中，男性E2/T增高，女性以E2降低最为明显。表明适当地调节性激素水平会有利于老年多梗塞痴呆及非痴呆性脑梗塞的防治。
목적：연구노년다경새성치태(MID)적성격소。방법：채취방사면역법측정노년다경새치태46례，노년비치태뇌경새(CI)62례，정상노년건강대조조38례。결과：남성MID조화CI조분별여대조조적비교， T치하강， E2/T증고，균유현저성차이(P<0.05)， MID조E2고우대조조，유현저성차이(P<0.05)， CI조여대조조E2비교무현저차이(P>0.05)。녀성MID조화CI조분별여대조조비교， T치하강，유현저성차이(P<0.05)， E2경명현하강，유고도현저차이(P<0.001)， PRL화PRO급E2/T치무현저성차이。남녀성노년다경새성치태여비치태성뇌경새조분별비교T、 PRO、 E2/T、균무현저성차이(P>0.05)。결론：노년다경새성치태여비치태성뇌경새도존재착성격소실형，기중，남성E2/T증고，녀성이E2강저최위명현。표명괄당지조절성격소수평회유리우노년다경새치태급비치태성뇌경새적방치。
Objective： To study the changes of sex hormones in multiple infarction dementia (MID) of old people. Methods: We used radioimmulogical method to examine 46 old patients with MID and 62 old patients with non-dementia cerebral infarction (CI) and 38 voluntxers with normal function. Results:To compare male MID group, non-dementia CI group with the control group respectively. the level of testosterones (T) was lower, E2/T was higer, E2/T was significantly higher (P<0.05). In MID group E2 was higher than that of the control group, E2 was significantly higher(P<0.05). To compare non-dementia CI group with the control group. E2 was not especially different(P>0.05). To compare female MID group, non-dementia CI group with the control group respectively, the level of testosterones (T) was significantly lower(P<0.05), E2 was more significantly low (P<0.001). Prolactin (PRL), Progesterone (PRO) and E2/T were not especially different. To compare male, female MID group with non-dementia CI group respectively, T, PRO, E2/T were not especially different(P>0.05). Conclusion: sex hormone ballance are broken in MID and non-dementia CI. E2/T was higer in male and E2 was lower obviously in female. To regulate the level of sex hormones properly is perhaps of benefit to prevent and treat MID and non-dementia CI.