临床心身疾病杂志
臨床心身疾病雜誌
림상심신질병잡지
JOURNAL OF CLINICAL PSYCHOSOMATIC DISEASES
2009年
4期
328-329
,共2页
情感障碍%躁狂发作%碳酸锂%喹硫平%Beck-Rafaelsen躁狂量表%副反应量表
情感障礙%躁狂髮作%碳痠鋰%喹硫平%Beck-Rafaelsen躁狂量錶%副反應量錶
정감장애%조광발작%탄산리%규류평%Beck-Rafaelsen조광량표%부반응량표
Affective disorder%manic episode%lithium carbonade%quetiapine%BRMS%TESS
目的 探讨碳酸锂联合喹硫平治疗急性躁狂发作的临床疗效和安全性. 方法 将90例急性躁狂发作患者随机分为两组各45例,两组均口服碳酸锂治疗,研究组在此基础上联合喹硫平治疗,观察8 w.于治疗前及治疗第1 w、2 w、4 w、6 w、8 w末采用Beck-Rafaelsen躁狂量表及副反应量表评定临床疗效及不良反应. 结果 治疗后研究组有效率显著高于对照组(P＜0.05);治疗2 w、4 w、6 w末Beck-Rafaelsen躁狂量表总分均较对照组下降显著(P＜0.05).两组不良反应程度较轻微,发生率及副反应量表总分均无显著性差异(P＞0.05);研究组合并应用氯硝西泮率显著低于对照组(P＜0.01). 结论 碳酸锂联合喹硫平治疗躁狂发作较单用碳酸锂起效更快,疗效更显著,且不良反应发生率较低,程度较轻微,是临床治疗急性躁狂发作的有效措施之一.
目的 探討碳痠鋰聯閤喹硫平治療急性躁狂髮作的臨床療效和安全性. 方法 將90例急性躁狂髮作患者隨機分為兩組各45例,兩組均口服碳痠鋰治療,研究組在此基礎上聯閤喹硫平治療,觀察8 w.于治療前及治療第1 w、2 w、4 w、6 w、8 w末採用Beck-Rafaelsen躁狂量錶及副反應量錶評定臨床療效及不良反應. 結果 治療後研究組有效率顯著高于對照組(P＜0.05);治療2 w、4 w、6 w末Beck-Rafaelsen躁狂量錶總分均較對照組下降顯著(P＜0.05).兩組不良反應程度較輕微,髮生率及副反應量錶總分均無顯著性差異(P＞0.05);研究組閤併應用氯硝西泮率顯著低于對照組(P＜0.01). 結論 碳痠鋰聯閤喹硫平治療躁狂髮作較單用碳痠鋰起效更快,療效更顯著,且不良反應髮生率較低,程度較輕微,是臨床治療急性躁狂髮作的有效措施之一.
목적 탐토탄산리연합규류평치료급성조광발작적림상료효화안전성. 방법 장90례급성조광발작환자수궤분위량조각45례,량조균구복탄산리치료,연구조재차기출상연합규류평치료,관찰8 w.우치료전급치료제1 w、2 w、4 w、6 w、8 w말채용Beck-Rafaelsen조광량표급부반응량표평정림상료효급불량반응. 결과 치료후연구조유효솔현저고우대조조(P＜0.05);치료2 w、4 w、6 w말Beck-Rafaelsen조광량표총분균교대조조하강현저(P＜0.05).량조불량반응정도교경미,발생솔급부반응량표총분균무현저성차이(P＞0.05);연구조합병응용록초서반솔현저저우대조조(P＜0.01). 결론 탄산리연합규류평치료조광발작교단용탄산리기효경쾌,료효경현저,차불량반응발생솔교저,정도교경미,시림상치료급성조광발작적유효조시지일.
Objeceive To explore the efficacy and safety of lithium carbonate plus quetiapine in the treatment of acute manic episode.Methods 90 patients with acute manic episode were randomly divided into two troups of 45 ones each, both groups took orally lithium carbonate,and research group was added quetiapine to for 8 weeks. Efficacies were assessed with the Bech-Rafaelsen Mania Rating Scale (BRMS) and adverse reactions with the Treatment Emergent Symptom Scale (TESS) before treatment and at the end of the 1st,2nd,4th, 6th and 8th week treatment. Results After treatment,effective rate was significantly higher in the research than in the control group(P<0.05); total scores of the BRMS lowered more significantly in the research than in the control group at the end of the 2nd,4th and 6th week(P<0.05).Adverse reactions of both groups were mild and there were no significant differences in incidences of adverse reactions and total scores of the TESS(P>0.05);The rate of combining clonazepam was significantly lower in the research than in the control group(P<0.01). Conclusion Lithium carbonaste combined with quetiapine has an advantage over single lithium carbonade,takes effect quicker, its efficacy is more significant,has lower and mild adverse reactions ans is one of effective methods treating acute manic episode.
