CAJ | 학술논문

胚胎干细胞因其具有体外无限增殖能力和体内外分化发育的全能性,有望为细胞治疗或组织工程化组织构建提供可靠的种子细胞来源.如何诱导胚胎干细胞向目的细胞分化是目前面临的一大难题.首先回顾软骨细胞的体内发生、发育过程,继而对目前已知的能在体外培养环境中影响胚胎干细胞向软骨细胞分化的各类因素进行分析综述,并探讨进一步的研究方向.
배태간세포인기구유체외무한증식능력화체내외분화발육적전능성,유망위세포치료혹조직공정화조직구건제공가고적충자세포래원.여하유도배태간세포향목적세포분화시목전면림적일대난제.수선회고연골세포적체내발생、발육과정,계이대목전이지적능재체외배양배경중영향배태간세포향연골세포분화적각류인소진행분석종술,병탐토진일보적연구방향.
Since the first successful establishment of human embryonic stem cell line in 1998,embryonic stem cell research has attracted much attention in recent years.Theoretically,embryonic stem cells are pluripotent 0f in vitro proliferation and in vivo differentiation.which could serve as a promising seed cell source for cell thera PY or tissue engineering.Differentiation of the embryonic stem cells into a certain type of cell still remains a big challenge.Studies regarding chondrogenic ifferentiation have been reported.This article summarizes the chon drogenic process in developing embryo and the currently known factors involved in the in vitro chondrogenic differentiation of embryonic stem cell.Foreground of the study in this field is discussed.