中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2010年
14期
1889-1890
,共2页
L-精氨酸%高血糖血管损伤%内皮功能
L-精氨痠%高血糖血管損傷%內皮功能
L-정안산%고혈당혈관손상%내피공능
L-Arginine%Vascular function,diabetes
目的 研究L-精氨酸对糖尿病引起的血管内皮功能损伤的保护作用和意义.方法 将60例糖尿病患者随机分为安慰剂对照组(n=30)和L-精氨酸治疗组(n=30).L-精氨酸对照组给予口服精氨酸7 g每天.两组治疗28 d后再过7 d的药物洗脱期.在治疗前和治疗后测定两组患者血浆一氧化氮(NO)、内皮素(ET)、血管性血友病因子(vWF)浓度及检测肱动脉血流介导的扩张反应(FMD),并进行分析.结果 L精氨酸治疗组较安慰剂对照组,血浆NO浓度升高,vWF和ET水平下降,差异有统计学意义(P＜0.05).同时L精氨酸治疗的FMD较对照组明显升高(P＜0.05).结论 L-精氨酸可影响血管内皮活性物质,影响血管内皮的收缩舒张作用,从而对高血糖伴随的血管损伤有保护作用.
目的 研究L-精氨痠對糖尿病引起的血管內皮功能損傷的保護作用和意義.方法 將60例糖尿病患者隨機分為安慰劑對照組(n=30)和L-精氨痠治療組(n=30).L-精氨痠對照組給予口服精氨痠7 g每天.兩組治療28 d後再過7 d的藥物洗脫期.在治療前和治療後測定兩組患者血漿一氧化氮(NO)、內皮素(ET)、血管性血友病因子(vWF)濃度及檢測肱動脈血流介導的擴張反應(FMD),併進行分析.結果 L精氨痠治療組較安慰劑對照組,血漿NO濃度升高,vWF和ET水平下降,差異有統計學意義(P＜0.05).同時L精氨痠治療的FMD較對照組明顯升高(P＜0.05).結論 L-精氨痠可影響血管內皮活性物質,影響血管內皮的收縮舒張作用,從而對高血糖伴隨的血管損傷有保護作用.
목적 연구L-정안산대당뇨병인기적혈관내피공능손상적보호작용화의의.방법 장60례당뇨병환자수궤분위안위제대조조(n=30)화L-정안산치료조(n=30).L-정안산대조조급여구복정안산7 g매천.량조치료28 d후재과7 d적약물세탈기.재치료전화치료후측정량조환자혈장일양화담(NO)、내피소(ET)、혈관성혈우병인자(vWF)농도급검측굉동맥혈류개도적확장반응(FMD),병진행분석.결과 L정안산치료조교안위제대조조,혈장NO농도승고,vWF화ET수평하강,차이유통계학의의(P＜0.05).동시L정안산치료적FMD교대조조명현승고(P＜0.05).결론 L-정안산가영향혈관내피활성물질,영향혈관내피적수축서장작용,종이대고혈당반수적혈관손상유보호작용.
Objective To explore the effects of L-Arginine on diabetic vascular endothelial function. Methods 60 patients with Diabetes were randomly divided into two group:placebo control group(30 patients)and L-Arginine group(30 patients). Patients in L-Arginine group were taken L-Arginine 7g a day. All patients were treated for 28days and other 7days for elution. The plasma concentration of nitric oxide(NO) and endothelin (ET), vWF were measured in each group before and after the experiment. Flow Mediated Dilation(FMD) function of brachial artery of all patients were measured by high resolution vascular ultrasound. Results After the experiment, the plasma concentration of NO in L-Arginine group was higher than that of placebo group, meanwhile the plasma concentration of ET and vWF were lower than placebo group (P ＜ 0. 05). Moreover, FDM in L-Arginine group were significant higher than placebo group(P ＜ 0. 05). Conclusion L-Arginine could protect the vascular function in the diabetic patients.
