CAJ | 학술논문

目的探讨微波消融区组织的弹性分布特征及其与温度分布之间的关系.方法在离体猪肝上用Thy-ablation微波消融针以变化的消融时间-功率组合制作不同的消融区模型,消融中对消融区的三个特征性位点进行实时电子测温,消融终止5 min后对相应位点的硬度特征采用弹性超声应变率比值(strain ratio,SR)进行定量研究.结果应变率比值和温度值由消融区的中心向边缘均呈梯度性递减,硬度回落与温度衰落方向性一致,二者间呈线性回归和相关,回归系数b=0.666,相关系数r=0.956(P＜0.001).中心区的温度和硬度受消融时间-功率组合影响变化较为明显,而边缘区受影响甚微,分别具有微波消融区边缘温度趋同效应和边缘硬度趋同效应现象.结论微波消融区内的温度和硬度均存在明显的不均匀性,但是变化具有梯度性改变的特点.认识和利用这些现象,有助于科学管控肿瘤的微波消融治疗.
목적 탐토미파소융구조직적탄성분포특정급기여온도분포지간적관계.방법 재리체저간상용Thy-ablation미파소융침이변화적소융시간-공솔조합제작불동적소융구모형,소융중대소융구적삼개특정성위점진행실시전자측온,소융종지5 min후대상응위점적경도특정채용탄성초성응변솔비치(strain ratio,SR)진행정량연구.결과 응변솔비치화온도치유소융구적중심향변연균정제도성체감,경도회락여온도쇠락방향성일치,이자간정선성회귀화상관,회귀계수b=0.666,상관계수r=0.956(P＜0.001).중심구적온도화경도수소융시간-공솔조합영향변화교위명현,이변연구수영향심미,분별구유미파소융구변연온도추동효응화변연경도추동효응현상.결론 미파소융구내적온도화경도균존재명현적불균균성,단시변화구유제도성개변적특점.인식화이용저사현상,유조우과학관공종류적미파소융치료.
Objective To explore the characteristics of changes in temperature and stiffness within the microwave-induced ablation region.Methods A type of Thy-ablation microwave antenna was used upon a design of various combination of ablation duration and power to induce heated region in samples of fresh porcine liver.Three special sites were set to assess the corresponding temperature and stiffness in each heated region.The temperature was continuously measured by using electronic thermometer with microwave on going,while stiffness was determined 5min after the ending of ablation by using real-time ultrasonic elastography,strain ratio,a quantitative indicator.Results The SR values and temperature determinations decreased progressively from the central to the peripheral area of the heated region.There was a linear regression between the temperatures (X) and SRs (Y),with Y =0.666 X-37.17.A significant correlation exists between X and Y,with the correlation coefficient being 0.956(P ＜0.001).The stiffness and temperature at the central sites are variable with the changes of both ablation time and power,but little changed at the peripheral sites of heated-region,which we name a phenomenon due to the ending effect of microwave propagation.Conclusions Temperature and stiffness increase considerably following microwave radiation but they are heterogeneously distributed within the ablated region in porcine liver.The characteristic gradient changes are confirmed of both temperature and the elasticity.It is presumable that good recognition and understanding and full utilization of these characteristics are conducive to reasonable control of tumor microwave ablation therapy.