CAJ | 학술논문

目的探讨系统性红斑狼疮(SLE)患者抗β2糖蛋白Ⅰ(β2GP Ⅰ)抗体的定量水平和临床意义,以及该抗体与血小板减少的相关性.方法采用酶联免疫吸附试验(ELISA)检测108例SLE患者(其中血小板减少者37例)、30例类风湿关节炎(RA)患者和30例正常人血清中的抗β2GPⅠ抗体水平.同时记录所有SLE患者的临床症状、各项实验室指标和其他自身抗体的水平.分析抗β2GP Ⅰ抗体与患者的临床特点以及各种实验室指标的关系及临床意义.结果抗β2GP Ⅰ抗体在SLE患者中的敏感性为19.44%(21/108),特异性为95.0%;在RA中的敏感性为10%(3/30);30例正常对照均为阴性.SLE组抗β2GP Ⅰ抗体水平显著高于正常组(P＜0.05).SLE组37例血小板减少患者中5例抗β2GP Ⅰ抗体阳性,该抗体与SLE血小板减少无关(r=-0.028,P＞0.05).抗β2GP Ⅰ抗体与抗心磷脂抗体呈正相关(r=0.566,P＜0.01);与其他临床及实验室指标无性;与SLE活动无关.结论抗β2GP Ⅰ抗体在SLE中有较高的特异性;与SLE血小板减少无关.
목적 탐토계통성홍반랑창(SLE)환자항β2당단백Ⅰ(β2GP Ⅰ)항체적정량수평화림상의의,이급해항체여혈소판감소적상관성.방법 채용매련면역흡부시험(ELISA)검측108례SLE환자(기중혈소판감소자37례)、30례류풍습관절염(RA)환자화30례정상인혈청중적항β2GPⅠ항체수평.동시기록소유SLE환자적림상증상、각항실험실지표화기타자신항체적수평.분석항β2GP Ⅰ항체여환자적림상특점이급각충실험실지표적관계급림상의의.결과 항β2GP Ⅰ항체재SLE환자중적민감성위19.44%(21/108),특이성위95.0%;재RA중적민감성위10%(3/30);30례정상대조균위음성.SLE조항β2GP Ⅰ항체수평현저고우정상조(P＜0.05).SLE조37례혈소판감소환자중5례항β2GP Ⅰ항체양성,해항체여SLE혈소판감소무관(r=-0.028,P＞0.05).항β2GP Ⅰ항체여항심린지항체정정상관(r=0.566,P＜0.01);여기타림상급실험실지표무성;여SLE활동무관.결론 항β2GP Ⅰ항체재SLE중유교고적특이성;여SLE혈소판감소무관.
Objective To investigate the clinical significance of anti-β2 glycoprotein Ⅰ(anti-β2GP Ⅰ)antibodies in patients with systemic lupus erythematosus(SLE)and to assess their association with lupus thrombocytopenia.Methods Anti-β2GP Ⅰ antibodies were tested in 108 SLE patients(including 37thrombocytopenia patients),30 patients with rheumatoid arthritis(RA)and 30 healthy individuals by enzyme-linked immunosorbent assay(ELISA).The clinical features and laboratory findings were collected,and the associations of anti-β2GP Ⅰ antibody with laboratory findings and disease activity were analyzed.Results Sensitivities of anti-β2GP Ⅰ antibody were 19.44%(21/108)in SLE and 10%(3/30)in RA,respectively.The specificity of anti-β2GP Ⅰ antibody was 95.0% in SLE.The anti-β2GP Ⅰ antibody titers of the SLE group were significantly higher than normal group(P ＜ 0.05).There was no significant correlation between anti-β2GP Ⅰ antibodies and thrombocytopenia(r =-0.028,P ＞0.05).Anti-β2GP Ⅰ antibody was positively correlated to anticardiolipin antibody(r = 0.566,P ＜ 0.01).No associations were found between anti-β2GP Ⅰ antibody and other clinical and laboratory features.There was no statistical correlation between the level of anti-β2GP Ⅰ antibody and SLEDAI scores.Conclusions Anti-β2GP Ⅰ antibody had high specificity in SLE.There was no significant correlation between anti-β2GP Ⅰ antibodies and lupus thrombocytopenia.