CAJ | 학술논문

凝血机制在慢性荨麻疹的发病中起着重要的作用。内、外源性凝血途径同时被激活，产生凝血酶。凝血酶是一种蛋白酶激活受体激动剂，可诱导肥大细胞释放组胺，从而诱发荨麻疹的发生。其病情严重性随着凝血因子数量的增高而加重。抗凝药物及蛋白酶抑制剂对部分难治性荨麻疹有一定疗效。概述近几年针对凝血机制治疗慢性荨麻疹的研究进展。
응혈궤제재만성담마진적발병중기착중요적작용。내、외원성응혈도경동시피격활，산생응혈매。응혈매시일충단백매격활수체격동제，가유도비대세포석방조알，종이유발담마진적발생。기병정엄중성수착응혈인자수량적증고이가중。항응약물급단백매억제제대부분난치성담마진유일정료효。개술근궤년침대응혈궤제치료만성담마진적연구진전。
Blood coagulation plays an important role in the pathogenesis of chronic urticaria. Both the intrinsic and extrinsic pathways of the coagulation cascade are activated in chronic urticaria, which in turn induce the generation of thrombin. Thrombin, as the agonist of proteinase-activated receptors, can induce histamine release from mast cells, and then cause the development of urticaria. The severity of urticaria is parallel to the quantity of coagulation factors. Anticoagulants and protease inhibitors have shown certain efficacy in the treatment of some refractory urticaria. This paper summarizes recent progress in the development of blood coagulation-targeting strategies for the treatment of chronic urticaria.