CAJ | 학술논문

目的探讨Spa-1在乳房外Paget病发生和转移中可能的作用.方法取17例原位乳房外Paget病和12例侵袭性乳房外Paget病患者皮损及9例正常人皮肤组织,用免疫组化分别检测Spa-1和Ki-67的表达.结果 Spa-1在胞质中显色,Ki-67在胞核中显色.Spa-1和Ki-67仅少量表达于正常人皮肤基底层,在乳房外Paget病肿瘤组织中的表达明显高于正常人皮肤(P<0.01).Spa-1在侵袭性乳房外Paget病肿瘤组织中表达明显高于原位乳房外Paget病(P<0.01).乳房外Paget病肿瘤组织中Spa-1的表达与Ki-67的表达呈正相关.结论 Spa-1在乳房外Paget病的发生发展中可能起作用.
목적 탐토Spa-1재유방외Paget병발생화전이중가능적작용.방법 취17례원위유방외Paget병화12례침습성유방외Paget병환자피손급9례정상인피부조직,용면역조화분별검측Spa-1화Ki-67적표체.결과 Spa-1재포질중현색,Ki-67재포핵중현색.Spa-1화Ki-67부소량표체우정상인피부기저층,재유방외Paget병종류조직중적표체명현고우정상인피부(P<0.01).Spa-1재침습성유방외Paget병종류조직중표체명현고우원위유방외Paget병(P<0.01).유방외Paget병종류조직중Spa-1적표체여Ki-67적표체정정상관.결론 Spa-1재유방외Paget병적발생발전중가능기작용.
Objective To investigate the potential role of Spa-1 in the development and metastasis of EMPD.Methods Tissue specimens were resected from 17 patients with primary EMPD,12 patients with invasive EMPD and 9 normal human controls.Immunohistochemistry was performed to measure the expression of spa-1 and Ki-67.Results Positive staining was observed for Spa-1 in cytoplasm,and for Ki-67 in cell nuclei.Spa-1 and Ki-67 were weakly expressed in the basal layer of normal skin.The expression of Spa-1 and Ki-67 in EMPD tissue were statistically higher than those in the normal control tissue (both P<0.01).Increased expression of Spa-1 was noted in invasive EMPD tissue compared with in situ EMPD tissue.The expression of Spa-1 was positively correlated with that of Ki-67 in the tissue of EMPD.Conclusion Spa-1 may play a certain role in the initiation and progression of EMPD.