CAJ | 학술논문

贫血是炎性肠病(IBD)患者常见且严重的并发症,贫血可致该类患者生活质量的下降及住院时间和住院次数的增加.大量研究及相关结论证实:(1)贫血情况在IBD中普遍存在;(2)尽管在很多情况下贫血与IBD患者疾病活动性相关,但许多缓解期患者同样存在贫血和铁、维生素B12和(或)叶酸的缺乏;(3)贫血或单纯缺铁即可对患者病情转归和生活质量造成严重影响;(4)口服铁剂受患者低吸收率、耐受差和肠道病变部位氧化应激反应的影响而疗效不佳;(5)静脉补铁有效率高,且可明显改善患者生活质量;(6)为达到理想的血红蛋白水平,联合应用促红细胞生成素(EPO)可使血红蛋白水平快速显著提高,进一步改善病情.因此,对于IBD患者,临床医生对贫血状况应该有全面认识以进一步指导临床工作.
빈혈시염성장병(IBD)환자상견차엄중적병발증,빈혈가치해류환자생활질량적하강급주원시간화주원차수적증가.대량연구급상관결론증실:(1)빈혈정황재IBD중보편존재;(2)진관재흔다정황하빈혈여IBD환자질병활동성상관,단허다완해기환자동양존재빈혈화철、유생소B12화(혹)협산적결핍;(3)빈혈혹단순결철즉가대환자병정전귀화생활질량조성엄중영향;(4)구복철제수환자저흡수솔、내수차화장도병변부위양화응격반응적영향이료효불가;(5)정맥보철유효솔고,차가명현개선환자생활질량;(6)위체도이상적혈홍단백수평,연합응용촉홍세포생성소(EPO)가사혈홍단백수평쾌속현저제고,진일보개선병정.인차,대우IBD환자,림상의생대빈혈상황응해유전면인식이진일보지도림상공작.
Anemia is a frequent and serious complication in patients with inflammatory bowel disease (IBD).One third of patients with inflammatory bowel disease suffers from recurrent anemia.Anemia is associated with a decrease in the quality of life and an increased rate of hospitalization.A number of studies have been conducted and the most relevant conclusions obtained are:(1)anemia is quite common in IBD; (2)although in many cases anemia parallels the clinical activity of the disease,many patients in remission have anemia, and iron, vitamin B12 and/or folic acid deficiency; (3)anemia, and also iron deficiency without anemia,have important consequences in the clinical status and quality of life of the patients; (4)oral iron supplement is limited by poor absorption,intolerance,and induction of oxidative stress at the site of bowel inflammation; (5) intravenous iron sucrose has a high efficiency and a significant improvement in the quality of life; (6)erythropoietin is needed in a significant number of cases to achieve normal hemoglobin levels.Combination therapy with erythropoietin leads to a faster and larger hemoglobin increase.Thus,clinicians caring for IBD patients should have a comprehensive knowledge of anemia,and apply recently published guidelines in clinical practice.